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[Effect of nooglutil on rats with intracerebral posttraumatic hematoma (hemorrhagic stroke)]. 2003
T L Garibova, and
I P Galaeva, and
T A Voronina, and
V A Kraĭneva, and
I G Kapitsa, and
S V Kirichenko, and
A N Makarenko, and
G R Mirzoian, and
E A Kuznetsova
Laboratory of Psychopharmacology, Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
The effect of the new nootropic drug nooglutyl, a positive modulator of AMPA-subtype glutamatergic receptors, was studied in rats with a model hemorrhagic stroke (HS)--posttraumatic hematoma induced by cerebral tissue destruction in the capsule interna region. Single intraperitoneal injections of nooglutyl (10 and 20 mg/kg) 3-4 h after operation decreased the HS-induced neurological deficiency, restored the coordination of movements, improved the passive avoidance reaction retrieval, and prevented the loss of experimental animals. The results show evidence of a pronounced neuroprotector action of nooglutyl in rats with the HS model.
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