Biomaterial Database

[Genetic variability of Bordetella pertussis strains. Part I. Current knowledge]. 2003

Anna Gzyl, and Ewa Augustynowicz, and Grzegorz Gniadek, and Janusz Slusarczyk

Zakład Badania Surowic i Szczepionek Państwowego Zakładu Higieny ul. Chocimska 24, 00-791 Warszawa. agzyl@pzh.gov.pl

Variability of B. pertussis genome concerning S1 subunit of pertussis toxin (ptxS1) and pertactin (prn) genes has recently been recognised. Studies clearly showed differences in the DNA patterns and ptxS1 and prn alleles present in B. pertussis strains used for production of pertussis component in the DTP vaccine, in comparison to strains presently isolated from clinical materials. This trend has been observed in highly immunized populations with a long history of pertussis vaccination (The Netherlands, Finland, Poland, USA). Different ptxS1 and prn allele distribution for different countries needs further careful monitoring.

UI	MeSH Term	Description	Entries
D010567	Pertussis Vaccine	A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)	Vaccine, Pertussis
D011993	Recombinant Fusion Proteins	Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.	Fusion Proteins, Recombinant,Recombinant Chimeric Protein,Recombinant Fusion Protein,Recombinant Hybrid Protein,Chimeric Proteins, Recombinant,Hybrid Proteins, Recombinant,Recombinant Chimeric Proteins,Recombinant Hybrid Proteins,Chimeric Protein, Recombinant,Fusion Protein, Recombinant,Hybrid Protein, Recombinant,Protein, Recombinant Chimeric,Protein, Recombinant Fusion,Protein, Recombinant Hybrid,Proteins, Recombinant Chimeric,Proteins, Recombinant Fusion,Proteins, Recombinant Hybrid
D001886	Bordetella pertussis	A species of gram-negative, aerobic bacteria that is the causative agent of WHOOPING COUGH. Its cells are minute coccobacilli that are surrounded by a slime sheath.	Bacterium tussis-convulsivae,Haemophilus pertussis,Hemophilus pertussis
D004269	DNA, Bacterial	Deoxyribonucleic acid that makes up the genetic material of bacteria.	Bacterial DNA
D005060	Europe	The continent north of AFRICA, west of ASIA and east of the ATLANTIC OCEAN.	Northern Europe,Southern Europe,Western Europe
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000483	Alleles	Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.	Allelomorphs,Allele,Allelomorph
D001425	Bacterial Outer Membrane Proteins	Proteins isolated from the outer membrane of Gram-negative bacteria.	OMP Proteins,Outer Membrane Proteins, Bacterial,Outer Membrane Lipoproteins, Bacterial
D014481	United States	A country in NORTH AMERICA between CANADA and MEXICO.
D014644	Genetic Variation	Genotypic differences observed among individuals in a population.	Genetic Diversity,Variation, Genetic,Diversity, Genetic,Diversities, Genetic,Genetic Diversities,Genetic Variations,Variations, Genetic