Biomaterial Database

[Genetic variability of Bordetella pertussis strains. Part II. Perspectives]. 2003

Anna Gzyl, and Ewa Augustynowicz, and Grzegorz Gniadek, and Janusz Slusarczyk

Zakład Badania Surowic i Szczepionek Państwowego Zakładu Higieny ul. Chocimska 24, 00-791 Warszawa. agzyl@pzh.gov.pl

In some highly immunized countries with long history of pertussis vaccination (The Netherlands, Finland, Poland, USA, France, Great Britain) differences in the DNA patterns and ptxS1 and prn alleles present in B. pertussis strains used for production of pertussis component in the DTP vaccine, in comparison to strains presently isolated from clinical materials have been found. Studies on efficacy of whole-cell and acellular pertussis vaccines in elimination of B. pertussis strains harbouring different gene variants in a particular country might indicate a need for a change of B. pertussis strains used for production of the vaccine against pertussis.

UI	MeSH Term	Description	Entries
D001886	Bordetella pertussis	A species of gram-negative, aerobic bacteria that is the causative agent of WHOOPING COUGH. Its cells are minute coccobacilli that are surrounded by a slime sheath.	Bacterium tussis-convulsivae,Haemophilus pertussis,Hemophilus pertussis
D004269	DNA, Bacterial	Deoxyribonucleic acid that makes up the genetic material of bacteria.	Bacterial DNA
D005060	Europe	The continent north of AFRICA, west of ASIA and east of the ATLANTIC OCEAN.	Northern Europe,Southern Europe,Western Europe
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000483	Alleles	Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.	Allelomorphs,Allele,Allelomorph
D014481	United States	A country in NORTH AMERICA between CANADA and MEXICO.
D014644	Genetic Variation	Genotypic differences observed among individuals in a population.	Genetic Diversity,Variation, Genetic,Diversity, Genetic,Diversities, Genetic,Genetic Diversities,Genetic Variations,Variations, Genetic
D014917	Whooping Cough	A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.	Pertussis,Bordetella pertussis Infection, Respiratory,Cough, Whooping,Pertusses
D015721	Diphtheria-Tetanus-Pertussis Vaccine	A vaccine consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and whole-cell PERTUSSIS VACCINE. The vaccine protects against diphtheria, tetanus, and whooping cough.	DPT Vaccine,DTP Vaccine,DTwP Vaccine,Diphtheria-Pertussis-Tetanus Vaccine,Di-Te-Per Vaccine,Di Te Per Vaccine,Diphtheria Pertussis Tetanus Vaccine,Diphtheria Tetanus Pertussis Vaccine,Vaccine, DPT,Vaccine, DTP,Vaccine, DTwP,Vaccine, Di-Te-Per,Vaccine, Diphtheria-Pertussis-Tetanus,Vaccine, Diphtheria-Tetanus-Pertussis
D037342	Pertussis Toxin	One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed of five subunits S1 - S5. S1 contains mono ADPribose transferase activity.	IAP Pertussis Toxin,Islet-Activating Protein,Pertussigen,Histamine-Sensitizing Factor,Islets-Activating Protein,Lymphocytosis-Promoting Factor,Histamine Sensitizing Factor,Islet Activating Protein,Islets Activating Protein,Lymphocytosis Promoting Factor,Pertussis Toxin, IAP,Toxin, IAP Pertussis,Toxin, Pertussis