-transparent.png){kind=logo}
We report the presence of platelet-activating factor (PAF-acether; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in small-intestinal and colonic mucosa of neonatal rats. The PAF-acether content was higher in the colon than in the small intestine, and was lower in the small intestine of 30-day-old animals than in 14-day-old animals. We also report that cultured intestinal epithelial cells (INT 407) produce PAF-acether when stimulated with the calcium ionophore A23187, and that homogenized INT 407 cells can degrade PAF-acether with the formation of lysoPAF-acether. These findings suggest that intestinal epithelial cells are able to produce and metabolize PAF-acether, a potent mediator of inflammation. The authors propose that this might contribute to the pathophysiology of inflammatory bowel disease.
B Kald, and
C Gustafson, and
L Franzén, and
B Weström, and
R Sjödahl, and
C Tagesson
December 1982,
Agents and actions,
B Kald, and
C Gustafson, and
L Franzén, and
B Weström, and
R Sjödahl, and
C Tagesson
January 1989,
Advances in prostaglandin, thromboxane, and leukotriene research,
B Kald, and
C Gustafson, and
L Franzén, and
B Weström, and
R Sjödahl, and
C Tagesson
January 1985,
Advances in prostaglandin, thromboxane, and leukotriene research,
B Kald, and
C Gustafson, and
L Franzén, and
B Weström, and
R Sjödahl, and
C Tagesson
January 1986,
Bulletin europeen de physiopathologie respiratoire,
B Kald, and
C Gustafson, and
L Franzén, and
B Weström, and
R Sjödahl, and
C Tagesson
December 1981,
Agents and actions,
B Kald, and
C Gustafson, and
L Franzén, and
B Weström, and
R Sjödahl, and
C Tagesson
March 1990,
Journal of leukocyte biology,
B Kald, and
C Gustafson, and
L Franzén, and
B Weström, and
R Sjödahl, and
C Tagesson
January 1988,
Progress in clinical and biological research,
B Kald, and
C Gustafson, and
L Franzén, and
B Weström, and
R Sjödahl, and
C Tagesson
January 1981,
Biochimie,
B Kald, and
C Gustafson, and
L Franzén, and
B Weström, and
R Sjödahl, and
C Tagesson
March 1982,
Thrombosis research,
B Kald, and
C Gustafson, and
L Franzén, and
B Weström, and
R Sjödahl, and
C Tagesson
January 1985,
Advances in prostaglandin, thromboxane, and leukotriene research,
