Biomaterial Database

Activation of the renal sympathetic nerve by leptin microinjection into the ventromedial hypothalamus in rats. 2003

Mamoru Tanida, and Katsuya Nagai, and Hidekazu Kaneko

Division of Protein Metabolism, Institute for Protein Research, Osaka University, Osaka, 565-0871, Japan.

Leptin produced in white adipose tissue activates sympathetic nerve activity via the ventromedial hypothalamus (VMH) within the central nervous system (CNS). Using an electrophysiological technique, we investigated whether direct microinjection of leptin into the VMH elevates renal sympathetic nerve activity (RSNA) and blood pressure (BP) in anesthetized rats. Microinjection of leptin (100 ng/microL) into the VMH caused significant activation of RSNA from 25 minutes after administration but no affect on BP. We concluded that leptin-induced elevation of RSNA is mediated via the VMH or its vicinity within the CNS.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008297	Male		Males
D008845	Microinjections	The injection of very small amounts of fluid, often with the aid of a microscope and microsyringes.	Microinjection
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013564	Sympathetic Nervous System	The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.	Nervous System, Sympathetic,Nervous Systems, Sympathetic,Sympathetic Nervous Systems,System, Sympathetic Nervous,Systems, Sympathetic Nervous
D014697	Ventromedial Hypothalamic Nucleus	A nucleus of the middle hypothalamus, the largest cell group of the tuberal region with small-to-medium size cells.	Hypothalamic Nucleus, Ventromedial,Nucleus, Ventromedial Hypothalamic
D017207	Rats, Sprague-Dawley	A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.	Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D020738	Leptin	A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.	Ob Protein,Obese Protein,Ob Gene Product,Obese Gene Product,Gene Product, Ob,Gene Product, Obese