Biomaterial Database

Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata. 2003

Toh-Seok Kam, and Huey-Shen Pang, and Tuck-Meng Lim

Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.

The ethanol extract of the leaves of Tabernaemontana divaricata (double flower variety) provided a total of 23 alkaloids, including the new aspidosperma alkaloids, taberhanine, voafinine, N-methylvoafinine, voafinidine, voalenine and the new bisindole alkaloid, conophyllinine in addition to the previously known, biologically active bisindole, conophylline and its congener, conofoline. The structures of the new alkaloids were established by spectroscopic methods. The preparation and characterization of the corresponding quinones of the biologically active bisindoles are also described in relation to a structure-activity study of these compounds with respect to their action in stimulating insulin expression.

UI	MeSH Term	Description	Entries
D007211	Indoles	Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
D013058	Mass Spectrometry	An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.	Mass Spectroscopy,Spectrometry, Mass,Spectroscopy, Mass,Spectrum Analysis, Mass,Analysis, Mass Spectrum,Mass Spectrum Analysis,Analyses, Mass Spectrum,Mass Spectrum Analyses,Spectrum Analyses, Mass
D015394	Molecular Structure	The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.	Structure, Molecular,Molecular Structures,Structures, Molecular
D019906	Nuclear Magnetic Resonance, Biomolecular	NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.	Biomolecular Nuclear Magnetic Resonance,Heteronuclear Nuclear Magnetic Resonance,NMR Spectroscopy, Protein,NMR, Biomolecular,NMR, Heteronuclear,NMR, Multinuclear,Nuclear Magnetic Resonance, Heteronuclear,Protein NMR Spectroscopy,Biomolecular NMR,Heteronuclear NMR,Multinuclear NMR,NMR Spectroscopies, Protein,Protein NMR Spectroscopies,Spectroscopies, Protein NMR,Spectroscopy, Protein NMR
D026121	Indole Alkaloids	Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN).	Indole Alkaloid,Alkaloid, Indole,Alkaloids, Indole
D030014	Tabernaemontana	A plant genus of the family APOCYNACEAE that contains bisindole alkaloids and IBOGAINE.	Anartia Plant,Bonafousia,Ervatamia,Iboga,Muntafara,Pagiantha,Peschiera,Pterotaberna,Reichardia,Sarcopharyngia,Stemmadenia,Taberna Plant,Tabernaemontaneae,Tabernanthe iboga,Anartia Plants,Bonafousias,Ervatamias,Ibogas,Muntafaras,Pagianthas,Peschieras,Plant, Taberna,Pterotabernas,Reichardias,Sarcopharyngias,Stemmadenias,Taberna Plants,Tabernaemontanas