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A case of chronic neutrophilic leukaemia associated with multiple myeloma is reported. The patient had a 6 months history of bruising and weight loss, and showed mature neutrophilic leukocytosis, hepatosplenomegaly, high neutrophil alkaline phosphatase score, hyperuricaemia, neutrophils with pseudotoxic granulation and scarce Döhle bodies; moreover, a monoclonal IgG lambda was detected amounting 57.3 g/L. The bone marrow was grossly hypercellular with marked myeloid hyperplasia and aggregates of immature plasma cells. After treatment during 1 year with melphalan and prednisone she is well, although persisting with neutrophilic leukocytosis, slight splenomegaly, and the monoclonal IgG decreased to 25.8 g/L.
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A Fernández Jurado, and
A Amián, and
J N Rodríguez, and
M L Martino, and
M Cañavate, and
D Prados
August 1993,
Journal of the American Academy of Dermatology,
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International journal of hematology,
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Internal medicine (Tokyo, Japan),
J C Diéguez, and
A Fernández Jurado, and
A Amián, and
J N Rodríguez, and
M L Martino, and
M Cañavate, and
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EJHaem,
J C Diéguez, and
A Fernández Jurado, and
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D Prados
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Recenti progressi in medicina,
J C Diéguez, and
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February 1984,
Tumori,
