-transparent.png){kind=logo}
As a continuing part of our study on the chemistry and antitumor activity of podophyllotoxin, 11 new C-4 S-substituted podophyllotoxin derivatives were synthesised and screened in vitro against L1210 leukemia and KB cells. Thus, 4'-demethylepipodophyllotoxin was reacted with thiols in the presence of BF3. Et2O or trifluroacetic acid to give thioethers. In addition, 4-bromo-4-deoxy-4'-demethylepipodophyllotoxin, when reacted with thiols, also gave rise to corresponding thioether (4-alkylthio-4-deoxy-4'-demethylepipodophyllotoxins). Compounds 10 and 12 have the same activity as etoposide in the inhibition against L1210 leukemia, and compounds 9, 10, 12 and 15 also have comparable activity with etoposide against KB cells.
Z G Wang, and
W Y Ma, and
B S Li, and
C N Zhang
February 1992,
Chemical & pharmaceutical bulletin,
Z G Wang, and
W Y Ma, and
B S Li, and
C N Zhang
January 1987,
Journal of medicinal chemistry,
Z G Wang, and
W Y Ma, and
B S Li, and
C N Zhang
November 2004,
Bioorganic & medicinal chemistry letters,
Z G Wang, and
W Y Ma, and
B S Li, and
C N Zhang
June 2010,
Chemical biology & drug design,
Z G Wang, and
W Y Ma, and
B S Li, and
C N Zhang
July 1985,
Chemical & pharmaceutical bulletin,
Z G Wang, and
W Y Ma, and
B S Li, and
C N Zhang
September 1998,
Journal of medicinal chemistry,
Z G Wang, and
W Y Ma, and
B S Li, and
C N Zhang
April 2005,
Archives of pharmacal research,
Z G Wang, and
W Y Ma, and
B S Li, and
C N Zhang
January 1990,
Cancer chemotherapy and pharmacology,
Z G Wang, and
W Y Ma, and
B S Li, and
C N Zhang
February 1996,
Bioorganic & medicinal chemistry,
Z G Wang, and
W Y Ma, and
B S Li, and
C N Zhang
March 1974,
Journal of medicinal chemistry,
