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Transsphenoidal hypophysectomy for four dogs with pituitary ACTH-producing adenoma. 2003
Yasushi Hara, and
Masahiro Tagawa, and
Hiroyuki Masuda, and
Toshinori Sako, and
Hidekazu Koyama, and
Hiromitsu Orima, and
Shinichiro Nakamura, and
Kimimasa Takahashi, and
Naoko Sanno, and
Akira Teramoto
Division of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Animal Science University, Tokyo, Japan.
Four dogs diagnosed as pituitary-dependent hyperadrenocorticism were treated with transsphenoidal hypophysectomy and postoperative hormone supplementation therapy. On histological examination of the resected tissues, the tumors were ACTH-producing adenoma of the anterior lobe. Clinical signs such as alopecia and calcinosis cutis, as well as endocrinological abnormalities, were markedly alleviated after surgery. The clinical courses of these 4 dogs suggest that transsphenoidal hypophysectomy may be a useful treatment for pituitary-dependent hyperadrenocorticism.
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