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The paper deals with the effect of glutoxim included into a preoperative preparation regimen on immunological parameters in patients with fibrocavernous pulmonary tuberculosis. On admission, all the patients had inadequate cellular immunity and activated humoral immunity. After termination of a course of glutoxim therapy, there was an increase in the baseline low values of lymphocytic proliferative activity, in the count of mature T lymphocytes, and in the production of IL-2 induced by phytohemagglutinin. At the same time the similar parameters remained unchanged in the control group. The drug exerted the most noticeable stimulating effect on cellular immunity in patients with a limited process. Glutoxim produced no noticeable effect on humoral immunity. The immunomodulating effect of glutoxim was followed by improvement of the clinical and X-ray pictures of the disease. In glutoxim-treated patients with baseline immunological disorders, progression was found to occur 1.5-2 times more infrequently than in the control group. Indications for the use of glutoxim in the treatment of tuberculosis are specified on the basis of the baseline immunological parameters of each patient.
B E Knoring, and
A O Avetisian, and
A V El'kin, and
L A Kozhemiakin, and
A S Simbirtsev, and
I Ia Sakharova, and
G P Loginova, and
N V Pigareva, and
Iu N Levashev
January 2007,
Problemy tuberkuleza i boleznei legkikh,
B E Knoring, and
A O Avetisian, and
A V El'kin, and
L A Kozhemiakin, and
A S Simbirtsev, and
I Ia Sakharova, and
G P Loginova, and
N V Pigareva, and
Iu N Levashev
November 1969,
Sovetskaia meditsina,
B E Knoring, and
A O Avetisian, and
A V El'kin, and
L A Kozhemiakin, and
A S Simbirtsev, and
I Ia Sakharova, and
G P Loginova, and
N V Pigareva, and
Iu N Levashev
January 1994,
Likars'ka sprava,
B E Knoring, and
A O Avetisian, and
A V El'kin, and
L A Kozhemiakin, and
A S Simbirtsev, and
I Ia Sakharova, and
G P Loginova, and
N V Pigareva, and
Iu N Levashev
September 1980,
Problemy tuberkuleza,
B E Knoring, and
A O Avetisian, and
A V El'kin, and
L A Kozhemiakin, and
A S Simbirtsev, and
I Ia Sakharova, and
G P Loginova, and
N V Pigareva, and
Iu N Levashev
September 1960,
Terapevticheskii arkhiv,
B E Knoring, and
A O Avetisian, and
A V El'kin, and
L A Kozhemiakin, and
A S Simbirtsev, and
I Ia Sakharova, and
G P Loginova, and
N V Pigareva, and
Iu N Levashev
January 2009,
Problemy tuberkuleza i boleznei legkikh,
B E Knoring, and
A O Avetisian, and
A V El'kin, and
L A Kozhemiakin, and
A S Simbirtsev, and
I Ia Sakharova, and
G P Loginova, and
N V Pigareva, and
Iu N Levashev
January 1991,
Problemy tuberkuleza,
B E Knoring, and
A O Avetisian, and
A V El'kin, and
L A Kozhemiakin, and
A S Simbirtsev, and
I Ia Sakharova, and
G P Loginova, and
N V Pigareva, and
Iu N Levashev
January 1994,
Problemy tuberkuleza,
B E Knoring, and
A O Avetisian, and
A V El'kin, and
L A Kozhemiakin, and
A S Simbirtsev, and
I Ia Sakharova, and
G P Loginova, and
N V Pigareva, and
Iu N Levashev
November 2017,
Immunobiology,
B E Knoring, and
A O Avetisian, and
A V El'kin, and
L A Kozhemiakin, and
A S Simbirtsev, and
I Ia Sakharova, and
G P Loginova, and
N V Pigareva, and
Iu N Levashev
June 1980,
Problemy tuberkuleza,
