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Fifteen samples of original plants of Rhizoma Cimicifuga were determined quickly and directly with the method of FTIR and comparing software. The results showed that the spectra of these samples were characteristic relying on the difference of chemical components and their content of related components. The difference of spectra among samples belonging to different families was distinct, and in different species with same genus too. To the same species, between two samples with different producing areas, or with same producing area but different collection date, the spectra were not obvious. This approach provide a quickly and accurately determination method of crude drug without extraction and separation.
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