-transparent.png){kind=logo}
[A simple method for preparation of 18alpha-glycyrretinic acid ant its derivatives]. 2003
D V Ignatov, and
Iu I Prokof'ev, and
O M Ipatova, and
V P Timofeev, and
N V Medvedeva, and
A Iu Misharin
Orekhovich Research Institute of Biomedicinal Chemistry, Russian Academy of Medical Sciences, Pogodinskaya ul. 10, Moscow, 119832 Russia.
Treatment of 18 beta-glycyrrhizic acid with a methanolic solution of HCl resulted in a 1:1 mixture of methyl esters of 18 alpha- and 18 beta-glycyrrhetinic acids. Benzoylation of the mixture led to methyl esters of 3-benzoyl-18 alpha-glycyrrhetinic acid and 3-benzoyl-18 beta-glycyrrhetinic acid, which were separated by chromatography on silica gel. 18 alpha-Glycyrrhetinic acid was prepared by alkaline hydrolysis of methyl 3-benzoyl-18 alpha-glycyrrhetinate and was further used for the syntheses of 3-keto-18 alpha-glycyrrhetinic acid and methyl esters of 18 alpha-glycyrrhetinic acid and 3-keto-18 alpha-glycyrrhetinic acid.
Related Publications
D V Ignatov, and
Iu I Prokof'ev, and
O M Ipatova, and
V P Timofeev, and
N V Medvedeva, and
A Iu Misharin
July 1962,
Journal of biochemistry,
D V Ignatov, and
Iu I Prokof'ev, and
O M Ipatova, and
V P Timofeev, and
N V Medvedeva, and
A Iu Misharin
January 1965,
Canadian journal of biochemistry,
D V Ignatov, and
Iu I Prokof'ev, and
O M Ipatova, and
V P Timofeev, and
N V Medvedeva, and
A Iu Misharin
November 1967,
The Biochemical journal,
D V Ignatov, and
Iu I Prokof'ev, and
O M Ipatova, and
V P Timofeev, and
N V Medvedeva, and
A Iu Misharin
June 1973,
Indian journal of biochemistry & biophysics,
D V Ignatov, and
Iu I Prokof'ev, and
O M Ipatova, and
V P Timofeev, and
N V Medvedeva, and
A Iu Misharin
September 1977,
Bulletin of environmental contamination and toxicology,
D V Ignatov, and
Iu I Prokof'ev, and
O M Ipatova, and
V P Timofeev, and
N V Medvedeva, and
A Iu Misharin
January 1980,
Preparative biochemistry,
D V Ignatov, and
Iu I Prokof'ev, and
O M Ipatova, and
V P Timofeev, and
N V Medvedeva, and
A Iu Misharin
June 1994,
Carbohydrate research,
D V Ignatov, and
Iu I Prokof'ev, and
O M Ipatova, and
V P Timofeev, and
N V Medvedeva, and
A Iu Misharin
May 1964,
Archives of biochemistry and biophysics,
D V Ignatov, and
Iu I Prokof'ev, and
O M Ipatova, and
V P Timofeev, and
N V Medvedeva, and
A Iu Misharin
May 2017,
Photochemistry and photobiology,
D V Ignatov, and
Iu I Prokof'ev, and
O M Ipatova, and
V P Timofeev, and
N V Medvedeva, and
A Iu Misharin
September 1984,
Acta pharmaceutica Hungarica,
