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Recent data indicate that a neuroimmune reaction might be responsible in part for neuronal death and cognitive deterioration in senile dementia. The potential involvement of brain histamine (HA) and interleukin-1 (IL-1) in this process has been previously documented. We have studied the concentration of serum HA in patients with Alzheimer's disease (AD) or multi-infarct dementia (MID) and in age-matched control subjects. Serum HA levels were significantly higher in AD (10.935 +/- 5.692 nM) and MID (8.521 +/- 3.44 nM) than in controls (5.533 +/- 2.567 nM) and correlated with mental performance as evaluated with the Mini-Mental State Examination (MMSE) (r = +0.493, p < 0.009). No correlation was found with cardiovascular parameters, cerebrovascular risk factors or age. Hyperactivation of the histaminergic system in AD at central and peripheral levels might reflect a neuroimmune reaction to brain tissue damage, a neurotrophic response, and/or a reactive process to regulate the IL-1 induced amyloid precursor protein (APP) overproduction.
R Cacabelos, and
L Fernández-Novoa, and
J M Pérez-Trullén, and
A Franco-Maside, and
X A Alvarez
January 1985,
Lancet (London, England),
R Cacabelos, and
L Fernández-Novoa, and
J M Pérez-Trullén, and
A Franco-Maside, and
X A Alvarez
October 1991,
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R Cacabelos, and
L Fernández-Novoa, and
J M Pérez-Trullén, and
A Franco-Maside, and
X A Alvarez
September 1983,
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R Cacabelos, and
L Fernández-Novoa, and
J M Pérez-Trullén, and
A Franco-Maside, and
X A Alvarez
July 1993,
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R Cacabelos, and
L Fernández-Novoa, and
J M Pérez-Trullén, and
A Franco-Maside, and
X A Alvarez
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Medizinische Monatsschrift fur Pharmazeuten,
R Cacabelos, and
L Fernández-Novoa, and
J M Pérez-Trullén, and
A Franco-Maside, and
X A Alvarez
April 1995,
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R Cacabelos, and
L Fernández-Novoa, and
J M Pérez-Trullén, and
A Franco-Maside, and
X A Alvarez
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R Cacabelos, and
L Fernández-Novoa, and
J M Pérez-Trullén, and
A Franco-Maside, and
X A Alvarez
March 1997,
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R Cacabelos, and
L Fernández-Novoa, and
J M Pérez-Trullén, and
A Franco-Maside, and
X A Alvarez
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R Cacabelos, and
L Fernández-Novoa, and
J M Pérez-Trullén, and
A Franco-Maside, and
X A Alvarez
January 1987,
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica,
