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Leptin seems to play a role in both food intake and energy balance as well as in the regulation of reproductive features. In order to investigate the regulation of testicular functions by leptin we analysed leptin concentrations in the semen of men with different andrological diseases. It was demonstrated that semen leptin concentrations were inversely correlated with serum testosterone levels and directly with serum leptin concentrations. Furthermore, semen leptin concentrations display only a fraction of serum leptin levels. Semen leptin levels of patients with azoospermia due to hypergonadotrophic hypogonadism, associated with increased follicle-stimulating hormone levels and of high-grade oligozoospermia, were significantly elevated (1.19 +/- 0.46 and 1.09 +/- 0.54 microg l(-1), respectively), while semen levels of leptin in patients with obstructive azoospermia (0.54 +/- 0.41 microg l(-1)) and low-grade oligozoospermia (0.54 +/- 0.34 microg ml(-1)) were comparable with those of normozoospermic men (0.21 +/- 0.21 microg l(-1)). Our data suggest that dysfunction of testicular epithelia as found in hypergonadotrophic hypogonadism and high-grade oligozoospermia with decreased testosterone levels causes elevated spermal leptin concentrations. However, the correlation of semen with serum leptin concentrations indicates that leptin is not actively transported but rather leaks through the blood-testis barrier.
H-U von Sobbe, and
C Koebnick, and
L Jenne, and
F Kiesewetter
September 1972,
Acta endocrinologica,
H-U von Sobbe, and
C Koebnick, and
L Jenne, and
F Kiesewetter
January 2002,
Journal of atherosclerosis and thrombosis,
H-U von Sobbe, and
C Koebnick, and
L Jenne, and
F Kiesewetter
June 2000,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
H-U von Sobbe, and
C Koebnick, and
L Jenne, and
F Kiesewetter
June 2008,
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie,
H-U von Sobbe, and
C Koebnick, and
L Jenne, and
F Kiesewetter
April 2000,
Journal of endocrinological investigation,
H-U von Sobbe, and
C Koebnick, and
L Jenne, and
F Kiesewetter
March 2014,
Clinical endocrinology,
H-U von Sobbe, and
C Koebnick, and
L Jenne, and
F Kiesewetter
January 2019,
Clinical EEG and neuroscience,
H-U von Sobbe, and
C Koebnick, and
L Jenne, and
F Kiesewetter
April 2003,
Eye (London, England),
H-U von Sobbe, and
C Koebnick, and
L Jenne, and
F Kiesewetter
January 2014,
Scandinavian journal of clinical and laboratory investigation,
H-U von Sobbe, and
C Koebnick, and
L Jenne, and
F Kiesewetter
November 1980,
Acta endocrinologica,
