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This investigation compared the effects of feeding rats diets containing food grade white oil processed by either conventional oleum treatment or the more modern method of catalytic hydrogenation. In two separate experiments, male or female Fischer-344 rats were given free access for 90 days to diets containing 0, 10, 100, 500, 5,000, 10,000, or 20,000 ppm of either oleum-treated white oil (OTWO) or hydrotreated white oil (HTWO). There were no mortalities and no adverse clinical signs associated with feeding either white oil. Treatment-related effects evidenced by hematological, clinical chemical, and pathological changes were generally dose-related and more marked in female than in male rats, and the OTWO caused a greater pathological response than the HTWO. Tissue residues of saturated hydrocarbons were up to 5.2 times higher in female rats than in males. Rats fed 5,000 ppm or more of either white oil showed dose-related alterations in several hematological and clinical chemistry variates associated mainly with hepatic damage or functional alteration. At necropsy, mesenteric lymph nodes were enlarged, and increases in weight of liver, kidney, and spleen were significant. Microscopic changes were characterized by multifocal lipogranulomata in mesenteric lymph node and liver. No changes were observed in rats fed OTWO or HTWO for 90 days at dietary concentrations of 10 or 100 ppm, equivalent to a minimum intake of 0.65 and 6.4 mg/kg/day, respectively. Differences in degree of pathological response associated with each oil may have been due to their differences in specification rather than processing method.
M K Baldwin, and
P H Berry, and
D J Esdaile, and
S L Linnett, and
J G Martin, and
G C Peristianis, and
R A Priston, and
B J Simpson, and
J D Smith
February 1995,
Drug and chemical toxicology,
M K Baldwin, and
P H Berry, and
D J Esdaile, and
S L Linnett, and
J G Martin, and
G C Peristianis, and
R A Priston, and
B J Simpson, and
J D Smith
January 1996,
Toxicologic pathology,
M K Baldwin, and
P H Berry, and
D J Esdaile, and
S L Linnett, and
J G Martin, and
G C Peristianis, and
R A Priston, and
B J Simpson, and
J D Smith
January 2023,
Foods (Basel, Switzerland),
M K Baldwin, and
P H Berry, and
D J Esdaile, and
S L Linnett, and
J G Martin, and
G C Peristianis, and
R A Priston, and
B J Simpson, and
J D Smith
June 1994,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
M K Baldwin, and
P H Berry, and
D J Esdaile, and
S L Linnett, and
J G Martin, and
G C Peristianis, and
R A Priston, and
B J Simpson, and
J D Smith
January 2004,
Toxicologic pathology,
M K Baldwin, and
P H Berry, and
D J Esdaile, and
S L Linnett, and
J G Martin, and
G C Peristianis, and
R A Priston, and
B J Simpson, and
J D Smith
January 1991,
International archives of occupational and environmental health,
M K Baldwin, and
P H Berry, and
D J Esdaile, and
S L Linnett, and
J G Martin, and
G C Peristianis, and
R A Priston, and
B J Simpson, and
J D Smith
December 1956,
Gan,
M K Baldwin, and
P H Berry, and
D J Esdaile, and
S L Linnett, and
J G Martin, and
G C Peristianis, and
R A Priston, and
B J Simpson, and
J D Smith
February 1996,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
M K Baldwin, and
P H Berry, and
D J Esdaile, and
S L Linnett, and
J G Martin, and
G C Peristianis, and
R A Priston, and
B J Simpson, and
J D Smith
January 1980,
Voprosy pitaniia,
M K Baldwin, and
P H Berry, and
D J Esdaile, and
S L Linnett, and
J G Martin, and
G C Peristianis, and
R A Priston, and
B J Simpson, and
J D Smith
June 1967,
Zeitschrift fur Tierphysiologie, Tierernahrung und Futtermittelkunde,
