BIOMAT Database Logo BIOMAT Database Logo

Widespread occurrence of multiple drug-resistant Salmonella typhi in India. 1992

E J Threlfall, and L R Ward, and B Rowe, and S Raghupathi, and V Chandrasekaran, and J Vandepitte, and P Lemmens
WHO Collaborating Centre for Phage Typing and Resistance in Enterobacteria, Central Public Health Laboratory, London, UK.

Sixteen multiple drug resistant strains of Salmonella typhi belonging to Vi-phage types E1 (14) and O (2) and isolated in Southeast India in 1991 were characterized. All strains were resistant to chloramphenicol and the majority to trimethoprim and ampicillin. In all strains these resistances were encoded by plasmids of the H1 incompatibility group with molecular weights ranging from 110 to 120 megadaltons. Physicians in European countries should be aware that treatment may fail if patients with typhoid fever who have recently returned from the Indian sub-continent are given first-line treatment with chloramphenicol, trimethoprim or ampicillin. With the possible exception of young children, ciprofloxacin is currently the best choice for treatment of such patients.

UI MeSH Term Description Entries
D007194 India A country in southern Asia, bordering the Arabian Sea and the Bay of Bengal, between Burma and Pakistan. The capitol is New Delhi. Republic of India
D010957 Plasmids Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS. Episomes,Episome,Plasmid
D002702 Chloramphenicol Resistance Nonsusceptibility of bacteria to the action of CHLORAMPHENICOL, a potent inhibitor of protein synthesis in the 50S ribosomal subunit where amino acids are added to nascent bacterial polypeptides. Chloramphenicol Resistances
D002939 Ciprofloxacin A broad-spectrum antimicrobial carboxyfluoroquinoline. Bay-09867,Ciprinol,Cipro,Ciprofloxacin Hydrochloride,Ciprofloxacin Hydrochloride Anhydrous,Ciprofloxacin Monohydrochloride Monohydrate,Anhydrous, Ciprofloxacin Hydrochloride,Bay 09867,Bay09867,Hydrochloride Anhydrous, Ciprofloxacin,Hydrochloride, Ciprofloxacin,Monohydrate, Ciprofloxacin Monohydrochloride,Monohydrochloride Monohydrate, Ciprofloxacin
D004352 Drug Resistance, Microbial The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS). Antibiotic Resistance,Antibiotic Resistance, Microbial,Antimicrobial Resistance, Drug,Antimicrobial Drug Resistance,Antimicrobial Drug Resistances,Antimicrobial Resistances, Drug,Drug Antimicrobial Resistance,Drug Antimicrobial Resistances,Drug Resistances, Microbial,Resistance, Antibiotic,Resistance, Drug Antimicrobial,Resistances, Drug Antimicrobial
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000668 Ampicillin Resistance Nonsusceptibility of a microbe to the action of ampicillin, a penicillin derivative that interferes with cell wall synthesis. Ampicillin Resistances,Resistance, Ampicillin,Resistances, Ampicillin
D001434 Bacteriophage Typing A technique of bacterial typing which differentiates between bacteria or strains of bacteria by their susceptibility to one or more bacteriophages. Phage Typing,Typing, Bacteriophage,Typing, Phage
D012485 Salmonella typhi A serotype of SALMONELLA ENTERICA which is the etiologic agent of TYPHOID FEVER. Salmonella enterica serovar Typhi,Salmonella typhosa
D014296 Trimethoprim Resistance Nonsusceptibility of bacteria to the action of TRIMETHOPRIM.

Related Publications

E J Threlfall, and L R Ward, and B Rowe, and S Raghupathi, and V Chandrasekaran, and J Vandepitte, and P Lemmens
Multiple-drug-resistant Salmonella typhi.
July 1993, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
E J Threlfall, and L R Ward, and B Rowe, and S Raghupathi, and V Chandrasekaran, and J Vandepitte, and P Lemmens
Multiple drug resistant Salmonella typhi in Bangladesh.
December 1986, Journal of diarrhoeal diseases research,
E J Threlfall, and L R Ward, and B Rowe, and S Raghupathi, and V Chandrasekaran, and J Vandepitte, and P Lemmens
Occurrence of multi-drug resistant Salmonella typhi in Calcutta.
July 1992, The Indian journal of medical research,
E J Threlfall, and L R Ward, and B Rowe, and S Raghupathi, and V Chandrasekaran, and J Vandepitte, and P Lemmens
Multidrug-resistant Salmonella typhi in India.
August 1999, Lancet (London, England),
E J Threlfall, and L R Ward, and B Rowe, and S Raghupathi, and V Chandrasekaran, and J Vandepitte, and P Lemmens
Multidrug resistant Salmonella typhi in India.
April 1993, Indian journal of pathology & microbiology,
E J Threlfall, and L R Ward, and B Rowe, and S Raghupathi, and V Chandrasekaran, and J Vandepitte, and P Lemmens
Drug-Resistant Salmonella typhi in Pakistan.
January 2020, Clinical pediatrics,
E J Threlfall, and L R Ward, and B Rowe, and S Raghupathi, and V Chandrasekaran, and J Vandepitte, and P Lemmens
Multidrug resistant Salmonella typhi in Bangalore, south India.
April 1994, Indian journal of medical sciences,
E J Threlfall, and L R Ward, and B Rowe, and S Raghupathi, and V Chandrasekaran, and J Vandepitte, and P Lemmens
Multidrug resistant Salmonella typhi in Calicut, south India.
March 1992, The Indian journal of medical research,
E J Threlfall, and L R Ward, and B Rowe, and S Raghupathi, and V Chandrasekaran, and J Vandepitte, and P Lemmens
Multi drug resistant Salmonella typhi in Bombay.
January 1993, Indian journal of pathology & microbiology,
E J Threlfall, and L R Ward, and B Rowe, and S Raghupathi, and V Chandrasekaran, and J Vandepitte, and P Lemmens
Therapeutic re-appraisal of multiple drug resistant Salmonella typhi (MDRST) in Pakistani children.
March 2002, JPMA. The Journal of the Pakistan Medical Association,
Copied contents to your clipboard!