BIOMAT Database Logo BIOMAT Database Logo

Mechanism of antibiotic efflux in Gram-negative bacteria. 2003

Helen I Zgurskaya, and Ganesh Krishnamoorthy, and Elena B Tikhonova, and Sze Y Lau, and Kelly L Stratton
University of Oklahoma, Department of Chemistry and Biochemistry, Norman, OK 73019, USA. elenaz@ou.edu

Active efflux of antibiotics mediated by multidrug transporters is a mechanistic basis of multidrug resistance in bacteria. The most versatile multidrug transporters are those found in Gram-negative bacteria. They have a high level of constitutive expression and provide an immediate response to structurally diverse antimicrobial agents including clinically important antibiotics. The versatility and efficiency of multidrug transporters in Gram-negative bacteria heavily depend on coupling of drug efflux with the transport across the outer membrane. The coupling is achieved through the assembly of multi-component protein complexes that span both the inner and the outer membranes of Gram-negative bacteria. In this review we discuss the mechanistic and structural features of multidrug efflux complexes with the major focus on the tight coupling of drug efflux with transport across the outer membrane.

UI MeSH Term Description Entries
D006090 Gram-Negative Bacteria Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method. Gram Negative Bacteria
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D001693 Biological Transport, Active The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy. Active Transport,Uphill Transport,Active Biological Transport,Biologic Transport, Active,Transport, Active Biological,Active Biologic Transport,Transport, Active,Transport, Active Biologic,Transport, Uphill
D024901 Drug Resistance, Multiple, Bacterial The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS). Drug Resistance, Extensive, Bacterial,Drug Resistance, Extensively, Bacterial,Extensive Antibacterial Drug Resistance,Extensively Antibacterial Drug Resistance,Multidrug Resistance, Bacterial,Multiple Antibacterial Drug Resistance,Bacterial Multidrug Resistance,Bacterial Multidrug Resistances,Resistance, Bacterial Multidrug
D027425 Multidrug Resistance-Associated Proteins A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins. Multidrug Resistance-Associated Protein,ATP-Binding Cassette, Sub-Family C Proteins,MOAT Protein,Multispecific Organic Anion Transport Proteins,Multispecific Organic Anion Transporter,ATP Binding Cassette, Sub Family C Proteins,Multidrug Resistance Associated Protein,Multidrug Resistance Associated Proteins,Resistance-Associated Protein, Multidrug

Related Publications

Helen I Zgurskaya, and Ganesh Krishnamoorthy, and Elena B Tikhonova, and Sze Y Lau, and Kelly L Stratton
The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.
April 2015, Clinical microbiology reviews,
Helen I Zgurskaya, and Ganesh Krishnamoorthy, and Elena B Tikhonova, and Sze Y Lau, and Kelly L Stratton
Antibiotic efflux pumps in Gram-negative bacteria: the inhibitor response strategy.
June 2007, The Journal of antimicrobial chemotherapy,
Helen I Zgurskaya, and Ganesh Krishnamoorthy, and Elena B Tikhonova, and Sze Y Lau, and Kelly L Stratton
Structure and mechanism of drug efflux machinery in Gram negative bacteria.
September 2008, Current drug targets,
Helen I Zgurskaya, and Ganesh Krishnamoorthy, and Elena B Tikhonova, and Sze Y Lau, and Kelly L Stratton
Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria.
February 2017, Nature microbiology,
Helen I Zgurskaya, and Ganesh Krishnamoorthy, and Elena B Tikhonova, and Sze Y Lau, and Kelly L Stratton
Efflux-mediated multiresistance in Gram-negative bacteria.
January 2004, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
Helen I Zgurskaya, and Ganesh Krishnamoorthy, and Elena B Tikhonova, and Sze Y Lau, and Kelly L Stratton
Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance.
January 2014, Future microbiology,
Helen I Zgurskaya, and Ganesh Krishnamoorthy, and Elena B Tikhonova, and Sze Y Lau, and Kelly L Stratton
Multidrug efflux pumps of gram-negative bacteria.
October 1996, Journal of bacteriology,
Helen I Zgurskaya, and Ganesh Krishnamoorthy, and Elena B Tikhonova, and Sze Y Lau, and Kelly L Stratton
Inhibitors of efflux pumps in Gram-negative bacteria.
August 2005, Trends in molecular medicine,
Helen I Zgurskaya, and Ganesh Krishnamoorthy, and Elena B Tikhonova, and Sze Y Lau, and Kelly L Stratton
RND efflux pumps in Gram-negative bacteria; regulation, structure and role in antibiotic resistance.
January 2020, Future microbiology,
Helen I Zgurskaya, and Ganesh Krishnamoorthy, and Elena B Tikhonova, and Sze Y Lau, and Kelly L Stratton
Multiply antibiotic-resistant gram-negative bacteria.
November 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
Copied contents to your clipboard!