Biomaterial Database

Lymphoid organ development and cell migration. 2003

Jason G Cyster

Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143-0414, USA. cyster@itsa.ucsf.edu

As we travel into a new century, confronted with new infectious diseases and bioweapon threats, with surgeons continuing to push the boundaries of what is transplantable, and with gene therapists working on ways to remedy a myriad of genetic diseases, the need for improved methods to augment and suppress immune function is paramount. The recent discovery that a novel immunosuppressant works by blocking lymphocyte egress from lymphoid organs provides a compelling example of how improved understanding of lymphoid organ function will contribute to future drug development and human health. This volume brings together reviews from leaders in the field of thymus and secondary lymphoid organ biology, including discussions on the roles of transcriptional regulators Foxn1, retinoid-related orphan receptor gamma and nuclear factor-kappaB in lymphoid organ development, the function of lymphotoxin and other cytokines in lymphoid tissue organization, the guidance activity of chemokines in a multitude of immune cell-positioning events, the mechanism of action of the immunosuppressant FTY720, and the application of two-photon laser scanning microscopy to reveal the dynamic behavior of lymphoid cells in the depths of these essential tissues.

UI	MeSH Term	Description	Entries
D008198	Lymph Nodes	They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.	Lymph Node,Node, Lymph,Nodes, Lymph
D008221	Lymphoid Tissue	Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS.	Lymphatic Tissue,Lymphatic Tissues,Lymphoid Tissues,Tissue, Lymphatic,Tissue, Lymphoid,Tissues, Lymphatic,Tissues, Lymphoid
D002465	Cell Movement	The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.	Cell Migration,Locomotion, Cell,Migration, Cell,Motility, Cell,Movement, Cell,Cell Locomotion,Cell Motility,Cell Movements,Movements, Cell
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013154	Spleen	An encapsulated lymphatic organ through which venous blood filters.
D013950	Thymus Gland	A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.	Thymus,Gland, Thymus,Glands, Thymus,Thymus Glands
D018928	Immunity, Mucosal	Nonsusceptibility to the pathogenic effects of foreign microorganisms or antigenic substances as a result of antibody secretions of the mucous membranes. Mucosal epithelia in the gastrointestinal, respiratory, and reproductive tracts produce a form of IgA (IMMUNOGLOBULIN A, SECRETORY) that serves to protect these ports of entry into the body.	Immune Response, Mucosal,Mucosal Immunity,Immune Responses, Mucosal,Mucosal Immune Response,Mucosal Immune Responses