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BRAF and K-ras gene mutations in human pancreatic cancers. 2003
Norihisa Ishimura, and
Kunihiro Yamasawa, and
Mohammad Azharul Karim Rumi, and
Yasunori Kadowaki, and
Shunji Ishihara, and
Yuji Amano, and
Yoshinori Nio, and
Tetsuya Higami, and
Yoshikazu Kinoshita
Second Department of Internal Medicine, Shimane Medical University, 89-1 Enya-cho, Izumo-shi, Shimane 693-8501, Japan.
We investigated the frequency of BRAF mutations in human pancreatic cancer specimens to determine its role in the development of pancreatic cancer. Nine pancreatic cancer samples without a K-ras codon 12 mutation and 19 with a K-ras mutation were included in the study. Analyses of the BRAF sequence revealed mutations in exon 15 (V599E) in two cases, both of which also exhibited a K-ras codon 12 mutation. No BRAF mutation was found in cases without a K-ras mutation. The BRAF V599E mutation was not found to be a major mutation in pancreatic cancers that had no K-ras codon 12 mutation.
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