BIOMAT Database Logo BIOMAT Database Logo

Demonstrating the intrinsic ion channel activity of virally encoded proteins. 2003

Marie L Kelly, and James A Cook, and Patricia Brown-Augsburger, and Beverly A Heinz, and Michele C Smith, and Lawrence H Pinto
Department of Physiology, Wayne State Medical School, Detroit, MI 48201, USA.

This review summarizes the types of evidence that can be invoked in order to demonstrate that a virally encoded protein possesses ion channel activity that is intrinsic to the life cycle of the virus. Ion channel activity has been proposed to be a key step in the life cycle of influenza virus, and the protein responsible for this activity has been proposed to be the M2 protein encoded by the virus. This review contrasts the evidence supporting the conclusion that the A/M2 protein of influenza A virus has intrinsic ion channel activity with the evidence that the 3AB protein encoded by the human rhinovirus possesses intrinsic ion channel activity.

UI MeSH Term Description Entries
D007473 Ion Channels Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS. Membrane Channels,Ion Channel,Ionic Channel,Ionic Channels,Membrane Channel,Channel, Ion,Channel, Ionic,Channel, Membrane,Channels, Ion,Channels, Ionic,Channels, Membrane
D007477 Ions An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D009975 Orthomyxoviridae A family of RNA viruses causing INFLUENZA and other respiratory diseases. Orthomyxoviridae includes INFLUENZAVIRUS A; INFLUENZAVIRUS B; INFLUENZAVIRUS C; INFLUENZAVIRUS D; ISAVIRUS; and THOGOTOVIRUS. Influenza Viruses,Myxoviruses,Orthomyxoviruses,Influenza Virus,Myxovirus,Orthomyxovirus
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012229 Rhinovirus A genus of PICORNAVIRIDAE inhabiting primarily the respiratory tract of mammalian hosts. It includes over 100 human serotypes associated with the COMMON COLD. Common Cold Virus,Coryza Viruses,Cold Virus, Common,Cold Viruses, Common,Common Cold Viruses,Coryza Virus,Rhinoviruses
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D014763 Viral Matrix Proteins Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell. Membrane Proteins, Viral,Viral M Proteins,Viral M Protein,Viral Membrane Proteins

Related Publications

Marie L Kelly, and James A Cook, and Patricia Brown-Augsburger, and Beverly A Heinz, and Michele C Smith, and Lawrence H Pinto
Computational Modeling of Virally-encoded Ion Channel Structure.
October 2022, Research square,
Marie L Kelly, and James A Cook, and Patricia Brown-Augsburger, and Beverly A Heinz, and Michele C Smith, and Lawrence H Pinto
Virally encoded chemokine binding proteins.
September 2005, Mini reviews in medicinal chemistry,
Marie L Kelly, and James A Cook, and Patricia Brown-Augsburger, and Beverly A Heinz, and Michele C Smith, and Lawrence H Pinto
Small potassium ion channel proteins encoded by chlorella viruses.
April 2004, Proceedings of the National Academy of Sciences of the United States of America,
Marie L Kelly, and James A Cook, and Patricia Brown-Augsburger, and Beverly A Heinz, and Michele C Smith, and Lawrence H Pinto
Virally encoded 7TM receptors.
March 2001, Oncogene,
Marie L Kelly, and James A Cook, and Patricia Brown-Augsburger, and Beverly A Heinz, and Michele C Smith, and Lawrence H Pinto
Identification of virally encoded microRNAs.
January 2007, Methods in enzymology,
Marie L Kelly, and James A Cook, and Patricia Brown-Augsburger, and Beverly A Heinz, and Michele C Smith, and Lawrence H Pinto
Antifungal activity of a virally encoded gene in transgenic wheat.
April 2000, Nature biotechnology,
Marie L Kelly, and James A Cook, and Patricia Brown-Augsburger, and Beverly A Heinz, and Michele C Smith, and Lawrence H Pinto
The first virally encoded cytochrome p450.
August 2009, Journal of virology,
Marie L Kelly, and James A Cook, and Patricia Brown-Augsburger, and Beverly A Heinz, and Michele C Smith, and Lawrence H Pinto
Genetic Diversity of Potassium Ion Channel Proteins Encoded by Chloroviruses That Infect Chlorella heliozoae.
June 2020, Viruses,
Marie L Kelly, and James A Cook, and Patricia Brown-Augsburger, and Beverly A Heinz, and Michele C Smith, and Lawrence H Pinto
The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth.
July 2018, Oncogene,
Marie L Kelly, and James A Cook, and Patricia Brown-Augsburger, and Beverly A Heinz, and Michele C Smith, and Lawrence H Pinto
Ion channel activity drives ion channel expression.
September 1998, The Journal of physiology,
Copied contents to your clipboard!