-transparent.png){kind=logo}
Inhibition of tetrahydrobiopterin (H4biopterin) biosynthesis in endothelial cells almost completely abolished the agonist-induced formation of endothelium-derived relaxing factor (EDRF) (NO). This inhibitory effect could be antagonized when H4biopterin biosynthesis was restored by activating a salvage pathway. These data indicate that the formation of EDRF strictly depends on the presence of intracellular H4biopterin, which, in addition to Ca2+, may represent a further physiological and/or pathophysiological regulatory of endothelial NO synthases.
Related Publications
K Schmidt, and
E R Werner, and
B Mayer, and
H Wachter, and
W R Kukovetz
October 1992,
Canadian journal of anaesthesia = Journal canadien d'anesthesie,
K Schmidt, and
E R Werner, and
B Mayer, and
H Wachter, and
W R Kukovetz
April 1995,
Sheng li ke xue jin zhan [Progress in physiology],
K Schmidt, and
E R Werner, and
B Mayer, and
H Wachter, and
W R Kukovetz
March 1991,
Proceedings of the National Academy of Sciences of the United States of America,
K Schmidt, and
E R Werner, and
B Mayer, and
H Wachter, and
W R Kukovetz
December 2010,
General physiology and biophysics,
K Schmidt, and
E R Werner, and
B Mayer, and
H Wachter, and
W R Kukovetz
November 1997,
Arquivos brasileiros de cardiologia,
K Schmidt, and
E R Werner, and
B Mayer, and
H Wachter, and
W R Kukovetz
February 1988,
Clinical and experimental pharmacology & physiology,
K Schmidt, and
E R Werner, and
B Mayer, and
H Wachter, and
W R Kukovetz
July 2013,
Circulation research,
K Schmidt, and
E R Werner, and
B Mayer, and
H Wachter, and
W R Kukovetz
December 1988,
The Journal of pharmacology and experimental therapeutics,
K Schmidt, and
E R Werner, and
B Mayer, and
H Wachter, and
W R Kukovetz
February 1991,
The Journal of pharmacology and experimental therapeutics,
K Schmidt, and
E R Werner, and
B Mayer, and
H Wachter, and
W R Kukovetz
July 1992,
Casopis lekaru ceskych,
