BIOMAT Database Logo BIOMAT Database Logo

Role of endothelin-1 in carrageenin-induced inflammation. 1992

A Bertelli, and A Clerico, and A Chicca, and L Giovannini, and A Gorio, and M A Romano
Department of Pharmacology, University of Milan, Italy.

Many vasal factors are produced during an experimental model of inflammation such as rat-paw oedema induced by carrageenin. We investigated whether among the other well-known mediators of inflammation, i.e. serotonin, PAF, eicosanoids and kinins, the peptide endothelin-1 is produced by this kind of inflammatory process caused by carrageenin. Our results indicated that plasma endothelin, and the tissue concentration of endothelin in the oedematous paw, is increased as compared to the control. Consequently, endothelin should also be considered as an important factor in inflammatory processes.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D011863 Radioimmunoassay Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation. Radioimmunoassays
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D002351 Carrageenan A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES. Carrageenin,iota-Carrageenan,kappa-Carrageenan,lambda-Carrageenan,iota Carrageenan,kappa Carrageenan,lambda Carrageenan
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D016232 Endothelins 21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides. Endothelium-Derived Vasoconstrictor Factors,Endothelin,Vasoconstrictor Factors, Endothelium-Derived
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

A Bertelli, and A Clerico, and A Chicca, and L Giovannini, and A Gorio, and M A Romano
IL-33/ST2 signalling contributes to carrageenin-induced innate inflammation and inflammatory pain: role of cytokines, endothelin-1 and prostaglandin E2.
May 2013, British journal of pharmacology,
A Bertelli, and A Clerico, and A Chicca, and L Giovannini, and A Gorio, and M A Romano
Role of prostaglandin E in carrageenin-induced inflammation in rats.
September 1976, Biochemical pharmacology,
A Bertelli, and A Clerico, and A Chicca, and L Giovannini, and A Gorio, and M A Romano
Protective role of propionyl carnitine in vascular disorders experimentally induced by endothelin (ET-1) serotonin and K-carrageenin.
January 1993, Drugs under experimental and clinical research,
A Bertelli, and A Clerico, and A Chicca, and L Giovannini, and A Gorio, and M A Romano
[Lambda-carrageenin-induced inflammation. 1. Circulatory disturbances and morphological characteristics following intrathoracic administration of lambda-carrageenin in rats].
July 1983, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
A Bertelli, and A Clerico, and A Chicca, and L Giovannini, and A Gorio, and M A Romano
The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model.
September 2016, Rhinology,
A Bertelli, and A Clerico, and A Chicca, and L Giovannini, and A Gorio, and M A Romano
Antiplasmin activity in carrageenin-induced inflammation of rats.
December 1981, International journal of tissue reactions,
A Bertelli, and A Clerico, and A Chicca, and L Giovannini, and A Gorio, and M A Romano
T-kininogen in rats with carrageenin-induced inflammation.
December 1986, Biochemical pharmacology,
A Bertelli, and A Clerico, and A Chicca, and L Giovannini, and A Gorio, and M A Romano
Endothelin-1 potentiates smoke-induced acute lung inflammation.
December 2008, Experimental lung research,
A Bertelli, and A Clerico, and A Chicca, and L Giovannini, and A Gorio, and M A Romano
Thrombosis induced by endothelin (ET-1) and carrageenin in rats treated with indomethacin and propionyl carnitine.
January 1993, Drugs under experimental and clinical research,
A Bertelli, and A Clerico, and A Chicca, and L Giovannini, and A Gorio, and M A Romano
TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells.
January 2018, American journal of physiology. Heart and circulatory physiology,
Copied contents to your clipboard!