BIOMAT Database Logo BIOMAT Database Logo

[Recombinant hirudin and its analogs--new perspectives in antithrombotic treatment]. 1992

K Lewandowski, and K Zawilska
Kliniki Hematologii Instytutu Chorób Wewnetrznych Akademii Medycznej im. Karola Marcinkowskiego, Poznaniu.

UI MeSH Term Description Entries
D011994 Recombinant Proteins Proteins prepared by recombinant DNA technology. Biosynthetic Protein,Biosynthetic Proteins,DNA Recombinant Proteins,Recombinant Protein,Proteins, Biosynthetic,Proteins, Recombinant DNA,DNA Proteins, Recombinant,Protein, Biosynthetic,Protein, Recombinant,Proteins, DNA Recombinant,Proteins, Recombinant,Recombinant DNA Proteins,Recombinant Proteins, DNA
D006629 Hirudins Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN. Hirudin
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013927 Thrombosis Formation and development of a thrombus or blood clot in BLOOD VESSELS. Atherothrombosis,Thrombus,Blood Clot,Blood Clots,Thromboses
D024764 Hirudin Therapy Use of HIRUDINS as an anticoagulant in the treatment of cardiological and hematological disorders.

Related Publications

K Lewandowski, and K Zawilska
[Antithrombotic effects of recombinant hirudin in mice and its mechanism].
April 2018, Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology,
K Lewandowski, and K Zawilska
Anticoagulant and antithrombotic actions of recombinant hirudin.
April 1991, Seminars in thrombosis and hemostasis,
K Lewandowski, and K Zawilska
Studies on antithrombotic effects of recombinant hirudin.
June 1989, Thrombosis research,
K Lewandowski, and K Zawilska
An objective perspective on recombinant hirudin: a new anticoagulant and antithrombotic agent.
February 1991, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
K Lewandowski, and K Zawilska
Antithrombotic effects of recombinant hirudin in different animal models.
January 1991, Haemostasis,
K Lewandowski, and K Zawilska
Use of recombinant hirudin as antithrombotic treatment in patients with heparin-induced thrombocytopenia.
September 1995, American journal of hematology,
K Lewandowski, and K Zawilska
Antithrombotic effects of recombinant hirudin in experimental angioplasty and intravascular thrombolysis.
February 1990, Thrombosis and haemostasis,
K Lewandowski, and K Zawilska
Antithrombotic action of recombinant hirudin in a venous thrombosis model.
January 1991, Haemostasis,
K Lewandowski, and K Zawilska
Coexpression of BiP increased antithrombotic hirudin production in recombinant Saccharomyces cerevisiae.
February 2003, Journal of biotechnology,
K Lewandowski, and K Zawilska
Tyrosine phosphorylation of recombinant hirudin increases affinity to thrombin and antithrombotic activity.
March 2024, Proteins,
Copied contents to your clipboard!