BIOMAT Database Logo BIOMAT Database Logo

[Enzyme and isoenzyme activity in patients with malignant tumors of the oral mucosa]. 1992

L S Bassalyk, and N K Gus'kova, and L P Pashintseva, and N V Liubimova

The activity and isoenzyme profile of lactate dehydrogenase (LDH), alkaline and acid phosphatase were studied in tumors of the tongue, cheek, oral floor, soft palate and palatine tonsils (n = 100), leukoplakia (n = 7) and in the oral mucosa at corresponding sites in healthy subjects (n = 66), to develop tests for early detection, monitoring and prognosis of oral cancer. Levels of alpha-amylase and acid phosphatase were measured in saliva and blood serum of patients with oral cancer and healthy subjects. The activity of LDH and alkaline and acid phosphatase in oral malignancies were 1.5-6 times that in normal mucosa, depending on tumor site. Changes in LDH isoenzyme profile consisted in an increased level of M-subunits (LDH-4 and 5) and a decreased concentration of N-subunits (LDH-1 and 2). With regards to acid phosphatase, an increase in the activity of its tartrate-inhibited fraction was observed. An increase in LDH and alkaline phosphatase activity was registered for oral precancer (leukoplakia), too, although it was less pronounced than in cancer. Changes in LDH isoenzyme profile matched those in cancer patients. A significant increase in the activity of alpha-amylase, acid phosphatase and the latter's tartrate-inhibited fraction was registered in saliva of oral cancer patients (86-96%). The credibility of enzyme activity measurement in saliva for evaluation of response and prognosis is discussed.

UI MeSH Term Description Entries
D007527 Isoenzymes Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics. Alloenzyme,Allozyme,Isoenzyme,Isozyme,Isozymes,Alloenzymes,Allozymes
D007770 L-Lactate Dehydrogenase A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist. Lactate Dehydrogenase,Dehydrogenase, L-Lactate,Dehydrogenase, Lactate,L Lactate Dehydrogenase
D007972 Leukoplakia, Oral A white patch seen on the oral mucosa. It is considered a premalignant condition and is often tobacco-induced. When evidence of Epstein-Barr virus is present, the condition is called hairy leukoplakia (LEUKOPLAKIA, HAIRY). Keratosis, Oral,Leukokeratosis, Oral,Keratoses, Oral,Leukokeratoses, Oral,Leukoplakias, Oral,Oral Keratoses,Oral Keratosis,Oral Leukokeratoses,Oral Leukokeratosis,Oral Leukoplakia,Oral Leukoplakias
D009061 Mouth Mucosa Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations. Buccal Mucosa,Oral Mucosa,Mucosa, Mouth,Mucosa, Oral
D009062 Mouth Neoplasms Tumors or cancer of the MOUTH. Cancer of Mouth,Mouth Cancer,Oral Cancer,Oral Neoplasms,Cancer of the Mouth,Neoplasms, Mouth,Neoplasms, Oral,Cancer, Mouth,Cancer, Oral,Cancers, Mouth,Cancers, Oral,Mouth Cancers,Mouth Neoplasm,Neoplasm, Mouth,Neoplasm, Oral,Oral Cancers,Oral Neoplasm
D004796 Clinical Enzyme Tests Analyses for a specific enzyme activity, or of the level of a specific enzyme that is used to assess health and disease risk, for early detection of disease or disease prediction, diagnosis, and change in disease status. Enzyme Tests, Clinical,Clinical Enzyme Test,Enzyme Test, Clinical,Test, Clinical Enzyme,Tests, Clinical Enzyme
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000135 Acid Phosphatase An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2. Acid beta-Glycerophosphatase,Acid beta Glycerophosphatase
D000469 Alkaline Phosphatase An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
D000516 alpha-Amylases Enzymes that catalyze the endohydrolysis of 1,4-alpha-glycosidic linkages in STARCH; GLYCOGEN; and related POLYSACCHARIDES and OLIGOSACCHARIDES containing 3 or more 1,4-alpha-linked D-glucose units. Taka-Amylase A,alpha-Amylase,Alpha-Amylase Bayer,Maxilase,Mégamylase,alpha-1,4-D-Glucanglucanohydrolase,Alpha Amylase Bayer,AlphaAmylase Bayer,Taka Amylase A,TakaAmylase A,alpha 1,4 D Glucanglucanohydrolase,alpha Amylase,alpha Amylases

Related Publications

L S Bassalyk, and N K Gus'kova, and L P Pashintseva, and N V Liubimova
[Malignant tumors of the oral mucosa].
July 1987, Anales de la Facultad de Odontologia,
L S Bassalyk, and N K Gus'kova, and L P Pashintseva, and N V Liubimova
[Combined treatment of malignant tumors of the oral mucosa].
January 1981, Stomatologiia,
L S Bassalyk, and N K Gus'kova, and L P Pashintseva, and N V Liubimova
[Enzyme activity pattern of human oral mucosa epithelium].
January 1968, Enzymologia biologica et clinica,
L S Bassalyk, and N K Gus'kova, and L P Pashintseva, and N V Liubimova
[Lactate dehydrogenase activity and isoenzyme patterns in the diagnosis of benign and malignant brain tumors].
June 1973, Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology,
L S Bassalyk, and N K Gus'kova, and L P Pashintseva, and N V Liubimova
Risk of the contralateral mucosa in patients with oral potentially malignant disorders.
January 2011, Asian Pacific journal of cancer prevention : APJCP,
L S Bassalyk, and N K Gus'kova, and L P Pashintseva, and N V Liubimova
Brushing of oral mucosa for diagnosis of HPV infection in patients with potentially malignant and malignant oral lesions.
January 2006, Molecular diagnosis & therapy,
L S Bassalyk, and N K Gus'kova, and L P Pashintseva, and N V Liubimova
[Changes in oral mucosa and tumors in elderly patients].
January 1990, Zeitschrift fur Gerontologie,
L S Bassalyk, and N K Gus'kova, and L P Pashintseva, and N V Liubimova
[Enzyme and isoenzyme analyses in various malignant human tissues].
January 1971, Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
L S Bassalyk, and N K Gus'kova, and L P Pashintseva, and N V Liubimova
Telomerase activity in premalignant and malignant lesions of human oral mucosa.
June 1997, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
L S Bassalyk, and N K Gus'kova, and L P Pashintseva, and N V Liubimova
[Late metastasis and the immediate causes of death in malignant tumors of the oral mucosa].
January 1979, Stomatologiia,
Copied contents to your clipboard!