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Fusidic acid and its sodium salt (fusidin) are anti-staphylococcal drugs. In vitro studies have shown that they prevent the lymphocyte co-stimulatory activities of the cytokines IL-1 and IL-6 in a manner similar to that of cyclosporin A, and prevent the inhibitory effect of IL-1 on glucose-induced insulin production. As IL-1 and IL-6 are thought to play a role in the pathogenesis of Type 1 diabetes, the aim of this study was to investigate whether fusidin could influence the disease incidence of the spontaneously diabetic BB rat model. Accordingly, a group of 50 BB rats receiving fusidin dissolved in their drinking water were compared to a control group of 55 rats over a period of 200 days. The incidence of diabetes was found to be 52% in the experimental group and 71% in the control group (P < 0.05). The degree of insulitis and the number of islets at histological examination were similar among the non-diabetic animals whereas the diabetic fusidin-treated animals showed a higher degree of islet preservation than the diabetic control rats. The results are highly indicative of an anti-diabetogenic effect of fusidin.
K Buschard, and
C Pedersen, and
S V Hansen, and
I Hageman, and
K Aaen, and
K Bendtzen
September 2002,
Pharmacology & toxicology,
K Buschard, and
C Pedersen, and
S V Hansen, and
I Hageman, and
K Aaen, and
K Bendtzen
February 1994,
Immunology,
K Buschard, and
C Pedersen, and
S V Hansen, and
I Hageman, and
K Aaen, and
K Bendtzen
January 2000,
Annals of clinical and laboratory science,
K Buschard, and
C Pedersen, and
S V Hansen, and
I Hageman, and
K Aaen, and
K Bendtzen
January 1991,
International journal of immunopharmacology,
K Buschard, and
C Pedersen, and
S V Hansen, and
I Hageman, and
K Aaen, and
K Bendtzen
October 1991,
Diabetes research (Edinburgh, Scotland),
K Buschard, and
C Pedersen, and
S V Hansen, and
I Hageman, and
K Aaen, and
K Bendtzen
January 1988,
Zeitschrift fur Versuchstierkunde,
K Buschard, and
C Pedersen, and
S V Hansen, and
I Hageman, and
K Aaen, and
K Bendtzen
February 1990,
Experimental and clinical endocrinology,
K Buschard, and
C Pedersen, and
S V Hansen, and
I Hageman, and
K Aaen, and
K Bendtzen
January 1989,
Thymus,
K Buschard, and
C Pedersen, and
S V Hansen, and
I Hageman, and
K Aaen, and
K Bendtzen
September 1992,
Scandinavian journal of immunology,
K Buschard, and
C Pedersen, and
S V Hansen, and
I Hageman, and
K Aaen, and
K Bendtzen
February 2005,
Digestive diseases and sciences,
