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This study was devoted to the simultaneous examination of the karyotype and the bone marrow histology in 33 patients suffering from chronic myeloid leukemia with the Ph1 chromosome. Some patients were evaluated in the beginning of the disease, others after evolution and treatment and some at both times. Supplementary abnormalities of the karyotype occurred in some patients before any treatment, but in most after evolution and treatment. The abnormalities encountered consisted in hypodiploidies, modifications of chromosome structure and hyperdiploidies. The additional abnormalities of the karyotype were in the majority of the patients accompanied by a bone marrow histology characterized by more pronounced blastic infiltration and precollagen fibrosis and evidence of bone lesions. The picture realized by the karyotype and the bone marrow histology allows a better evaluation of the evolution and the prognosis is individual cases, especially of the likely hood of the acute blastic transformation.
J L Michaux, and
H Van Den Berghe, and
J Rodhain, and
G Sokal, and
G David, and
R Hulhoven
January 1975,
Nouvelle revue francaise d'hematologie,
J L Michaux, and
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R Hulhoven
January 1980,
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J L Michaux, and
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May 1976,
Scandinavian journal of haematology,
J L Michaux, and
H Van Den Berghe, and
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G Sokal, and
G David, and
R Hulhoven
January 1998,
Haematologia,
J L Michaux, and
H Van Den Berghe, and
J Rodhain, and
G Sokal, and
G David, and
R Hulhoven
July 1980,
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J L Michaux, and
H Van Den Berghe, and
J Rodhain, and
G Sokal, and
G David, and
R Hulhoven
May 1981,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
J L Michaux, and
H Van Den Berghe, and
J Rodhain, and
G Sokal, and
G David, and
R Hulhoven
June 1981,
Cancer genetics and cytogenetics,
J L Michaux, and
H Van Den Berghe, and
J Rodhain, and
G Sokal, and
G David, and
R Hulhoven
January 1980,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
J L Michaux, and
H Van Den Berghe, and
J Rodhain, and
G Sokal, and
G David, and
R Hulhoven
July 1979,
Blood,
J L Michaux, and
H Van Den Berghe, and
J Rodhain, and
G Sokal, and
G David, and
R Hulhoven
December 1978,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
