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We previously demonstrated the existence of a third component, p64, of IL-2 receptor (IL-2R), tentatively named the gamma chain of IL-2R. Our recent studies provided evidence suggesting that the gamma chain endows the beta chain of IL-2R with IL-2 binding ability. The gamma chain was detected in lymphoid transfectants of IL-2R beta cDNA, which showed the intermediate-affinity IL-2R, but not in nonlymphoid transfectants of IL-2R beta cDNA, which showed no IL-2 binding activity. The comparative study between two subclones of lymphoid MOLT4 transfectant of IL-2R beta cDNA demonstrated that the amount of the gamma chain coprecipitated with IL-2R beta was proportional to numbers of the IL-2 binding sites. These results suggest the possibility that the gamma chain associates with IL-2R beta and has an important role in formation of the intermediate-affinity IL-2R complex. On the other hand, we have also demonstrated the association of IL-2R beta with a certain tyrosine kinase, of which activation by IL-2 could be indispensable process at the initial pathway of signal transduction.
K Sugamura, and
T Takeshita, and
H Asao, and
S Kumaki, and
K Ohbo, and
K Ohtani, and
M Nakamura
February 1995,
European journal of immunology,
K Sugamura, and
T Takeshita, and
H Asao, and
S Kumaki, and
K Ohbo, and
K Ohtani, and
M Nakamura
October 1993,
International immunology,
K Sugamura, and
T Takeshita, and
H Asao, and
S Kumaki, and
K Ohbo, and
K Ohtani, and
M Nakamura
June 1994,
Journal of immunology (Baltimore, Md. : 1950),
K Sugamura, and
T Takeshita, and
H Asao, and
S Kumaki, and
K Ohbo, and
K Ohtani, and
M Nakamura
March 1990,
Seminars in immunology,
K Sugamura, and
T Takeshita, and
H Asao, and
S Kumaki, and
K Ohbo, and
K Ohtani, and
M Nakamura
December 1989,
European journal of immunology,
K Sugamura, and
T Takeshita, and
H Asao, and
S Kumaki, and
K Ohbo, and
K Ohtani, and
M Nakamura
January 1991,
International immunology,
K Sugamura, and
T Takeshita, and
H Asao, and
S Kumaki, and
K Ohbo, and
K Ohtani, and
M Nakamura
September 1995,
The Journal of biological chemistry,
K Sugamura, and
T Takeshita, and
H Asao, and
S Kumaki, and
K Ohbo, and
K Ohtani, and
M Nakamura
September 1993,
Journal of immunology (Baltimore, Md. : 1950),
K Sugamura, and
T Takeshita, and
H Asao, and
S Kumaki, and
K Ohbo, and
K Ohtani, and
M Nakamura
September 1995,
The Journal of biological chemistry,
K Sugamura, and
T Takeshita, and
H Asao, and
S Kumaki, and
K Ohbo, and
K Ohtani, and
M Nakamura
November 1994,
Molecular and cellular biology,
