Biomaterial Database

Metabolic and hormonal effects of exercise in mild streptozotocin diabetes. 1976

V A Koivisto, and H K Akerblom, and A Nikkilä

Metabolic and hormonal changes produced by muscular exercise were studied in rats with mild streptozotocin diabetes. In both diabetic and control animals the mean blood glucose increased and liver glycogen decreased during exercise. The postexercise blood glucose level correlated with the liver glycogen content in diabetic rats. A decrease of blood glucose occurred in some diabetic animals, and these also showed a decrease of liver glycogen to very low levels during exercise. During exercise the rise of plasma glycerol was higher in diabetic than in control animals, but changes in circulating free fatty acids, acetone bodies, insulin, corticosterone, lactate, and acid-base equilibrium were similar in the two groups. The results indicate that the only abnormal metabolic response to exercise in rats with mild diabetes is a slight increase of lipid mobilization.

UI	MeSH Term	Description	Entries
D008053	Lipid Mobilization	LIPOLYSIS of stored LIPIDS in the ADIPOSE TISSUE to release FREE FATTY ACIDS. Mobilization of stored lipids is under the regulation of lipolytic signals (CATECHOLAMINES) or anti-lipolytic signals (INSULIN) via their actions on the hormone-sensitive LIPASE. This concept does not include lipid transport.	Lipid Mobilizations,Mobilization, Lipid,Mobilizations, Lipid
D008112	Liver Glycogen	Glycogen stored in the liver. (Dorland, 28th ed)	Hepatic Glycogen,Glycogen, Hepatic,Glycogen, Liver
D008297	Male		Males
D001786	Blood Glucose	Glucose in blood.	Blood Sugar,Glucose, Blood,Sugar, Blood
D003920	Diabetes Mellitus	A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
D005082	Physical Exertion	Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.	Physical Effort,Effort, Physical,Efforts, Physical,Exertion, Physical,Exertions, Physical,Physical Efforts,Physical Exertions
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013311	Streptozocin	An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.	Streptozotocin,2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose,Streptozotocine,Zanosar
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus