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The effect of a single dose of intermediate acting (Lente) insulin given subcutaneously at 9.00 P.M. in 22 NIDDM subjects refractory to a combination of Sulphonylureas and Biguanides was analysed. Euglycemia was achieved and maintained during the study period of three months with a mean insulin requirement of 14.22 +/- 5.98 units/day. Plasma FFA, Total cholesterol, triglyceride and VLDL-cholesterol also showed significant reduction. The level of FFA modulates hepatic glucose production, which in turn correlates positively with the fasting blood glucose. The therapeutic modality of bed time Lente Insulin based on physiological principles is an effective way of achieving glycemic control in NIDDM subjects who have become non-responsive to oral hypoglycemic agents.
V Seshiah, and
R Shanker, and
R Madhavan, and
S Venkataraman, and
A Sundaram, and
C Seshasaianam, and
J R Sankaran
February 1993,
The Journal of the Association of Physicians of India,
V Seshiah, and
R Shanker, and
R Madhavan, and
S Venkataraman, and
A Sundaram, and
C Seshasaianam, and
J R Sankaran
August 1990,
Diabetes care,
V Seshiah, and
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S Venkataraman, and
A Sundaram, and
C Seshasaianam, and
J R Sankaran
July 1986,
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V Seshiah, and
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J R Sankaran
July 1970,
Indian journal of medical sciences,
V Seshiah, and
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S Venkataraman, and
A Sundaram, and
C Seshasaianam, and
J R Sankaran
March 2015,
Nihon rinsho. Japanese journal of clinical medicine,
V Seshiah, and
R Shanker, and
R Madhavan, and
S Venkataraman, and
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C Seshasaianam, and
J R Sankaran
August 1971,
Australian and New Zealand journal of medicine,
V Seshiah, and
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A Sundaram, and
C Seshasaianam, and
J R Sankaran
September 1995,
Diabetes,
V Seshiah, and
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A Sundaram, and
C Seshasaianam, and
J R Sankaran
March 1985,
Recenti progressi in medicina,
V Seshiah, and
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R Madhavan, and
S Venkataraman, and
A Sundaram, and
C Seshasaianam, and
J R Sankaran
September 1991,
Diabetes care,
V Seshiah, and
R Shanker, and
R Madhavan, and
S Venkataraman, and
A Sundaram, and
C Seshasaianam, and
J R Sankaran
July 1995,
Diabetes care,
