Biomaterial Database

[The influence of DDT analogues (nuarimol and fenarimol) on the frequency of occurrence of micronuclei in erythrocytes of bone marrow and spleen in mice]. 1992

E Tyrkiel, and J K Ludwicki

Zakładu Toksykologii Srodowiskowej Państwowego Zakładu Higieny, Warszawie.

The clastogenic potential of the two DDT analogues: fenarimol and nuarimol was investigated, and the usefulness of the mouse spleen cells for this purpose was evaluated. Nuarimol and fenarimol were administered per o to 8-10 weeks old male mice (Swiss) according to the following protocol: nuarimol 100 and 200 mg/kg b.w. and fenarimol 50 and 100 mg/kg b.w. twice during 24 hours. Mitomycin C (2 and 4 mg/kg b.w.) and cyclophosphamide (25 and 75 mg/kg b.w.) were administered to the positive control mice. After 30, 48, 72 hours following the first administration the animals were killed and the number of micronuclei were calculated in spleen and bone marrow polychromatic and normochromatic erythrocytes. The results show that the spleen could be regarded as an appropriate tissue for the evaluation of micronuclei induction. Fenarimol and nuarimol did not cause micronuclei induction in the bone marrow and spleen erythrocytes.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D011743	Pyrimidines	A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
D001853	Bone Marrow	The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.	Marrow,Red Marrow,Yellow Marrow,Marrow, Bone,Marrow, Red,Marrow, Yellow
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D005659	Fungicides, Industrial	Chemicals that kill or inhibit the growth of fungi in agricultural applications, on wood, plastics, or other materials, in swimming pools, etc.	Industrial Fungicides
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013154	Spleen	An encapsulated lymphatic organ through which venous blood filters.
D015162	Micronucleus Tests	Induction and quantitative measurement of chromosomal damage leading to the formation of micronuclei (MICRONUCLEI, CHROMOSOME-DEFECTIVE) in cells which have been exposed to genotoxic agents or IONIZING RADIATION.	Micronucleus Assays,Assay, Micronucleus,Assays, Micronucleus,Micronucleus Assay,Micronucleus Test,Test, Micronucleus,Tests, Micronucleus
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus