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A human melanoma cell line established in our laboratory was characterized in terms of tyrosinase activity and anionic polysaccharide production. Tyrosinase levels were diluted during the growth phase and increased after the cell culture became confluent. The anionic polysaccharides produced included hyaluronic acid, heparitin sulfate, and a high-molecular-weight condroitin 4-sulfate. In contrast, a primary culture of human melanocytes derived from embryonic iris produced much greater amounts of hyaluronic acid, about 30-fold less heparitin sulfate, and a mixture of chondroitin 4-sulfate and dermatan sulfate. Saccharides secreted into the culture medium were generally identical to those remaining cell associated except for the melanoma heparitin sulfate, wherein the latter fraction appeared to be of lower molecular weight.
J Banks, and
J W Kreider, and
V P Bhavanandan, and
E A Davidson
January 1989,
Acta dermato-venereologica,
J Banks, and
J W Kreider, and
V P Bhavanandan, and
E A Davidson
September 2013,
Molecular medicine reports,
J Banks, and
J W Kreider, and
V P Bhavanandan, and
E A Davidson
August 1980,
Journal of cellular physiology,
J Banks, and
J W Kreider, and
V P Bhavanandan, and
E A Davidson
March 1984,
Journal of the National Cancer Institute,
J Banks, and
J W Kreider, and
V P Bhavanandan, and
E A Davidson
May 2022,
Oncology letters,
J Banks, and
J W Kreider, and
V P Bhavanandan, and
E A Davidson
January 1973,
Developmental biology,
J Banks, and
J W Kreider, and
V P Bhavanandan, and
E A Davidson
February 1989,
Cancer research,
J Banks, and
J W Kreider, and
V P Bhavanandan, and
E A Davidson
July 1983,
Journal of cellular physiology,
J Banks, and
J W Kreider, and
V P Bhavanandan, and
E A Davidson
January 1990,
Acta dermato-venereologica,
J Banks, and
J W Kreider, and
V P Bhavanandan, and
E A Davidson
December 1993,
The Journal of investigative dermatology,
