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Application of harmine (10 mg/kg IP) 30 min before apomorphine decreased the motoric effects of the latter. Following harmine an increase in 5-HT and a decrease in 5-HIAA in different brain regions have been found. Injection of 5,6-DHT into nucleus medianus raphe 7 days before the experiment caused a significant increase of the apomorphine effect. Harmine pretreatment reduced this escessive motility as well as additional lesion of the substantia nigra with 6-OH-DA. Lesion induced by 6-OH-DA alone was without significant effect on the hypermotility following apomorphine. Application of PCPA 3 days before testing elicited an increase of apomorphine-induced hypermotolity which could be abolished by preceding harmine application. The experiments demonstrate the inhibitory effect of the central serotoninergic system on the apomorphine syndrome as well as the serotoninergic-dopaminergic interaction in hypermotility.
K H Westermann, and
K Funk, and
L Pawlowski
September 1995,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
K H Westermann, and
K Funk, and
L Pawlowski
January 1978,
Acta physiologica Polonica,
K H Westermann, and
K Funk, and
L Pawlowski
October 1981,
Japanese journal of pharmacology,
K H Westermann, and
K Funk, and
L Pawlowski
January 1960,
Transactions of the American Neurological Association,
K H Westermann, and
K Funk, and
L Pawlowski
June 1969,
Electroencephalography and clinical neurophysiology,
K H Westermann, and
K Funk, and
L Pawlowski
January 1998,
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova,
K H Westermann, and
K Funk, and
L Pawlowski
September 1980,
Pharmacology, biochemistry, and behavior,
K H Westermann, and
K Funk, and
L Pawlowski
November 1980,
Biulleten' eksperimental'noi biologii i meditsiny,
K H Westermann, and
K Funk, and
L Pawlowski
January 1977,
Polish journal of pharmacology and pharmacy,
K H Westermann, and
K Funk, and
L Pawlowski
September 1990,
Journal of pharmacological methods,
