-transparent.png){kind=logo}
Recombinant vaccinia viruses expressing wild type intracellular VP7 (VP7wt) from rotavirus SA11 or VP7sc, a cell surface-anchored variant, boosted antibody titres in SA11-immune mice. Pups born to these mice were protected from diarrhoea following challenge with SA11. In rotavirus-naive mice, two immunizations with recombinant vaccinia virus expressing VP7sc stimulated protective immunity that could be transferred to pups, whereas viruses expressing VP7wt did not stimulate protective immunity. Recombinant vaccinia viruses expressing intracellular or cell surface-anchored VP6, the rotavirus group-reactive antigen from the inner capsid, did not stimulate protective immunity. These experiments demonstrate that a live viral vector expressing cell surface anchored VP7 may represent a strategy for the development of safe, effective vaccines against rotavirus-induced diarrhoea.
M E Andrew, and
D B Boyle, and
B E Coupar, and
D Reddy, and
A R Bellamy, and
G W Both
November 1987,
Virus genes,
M E Andrew, and
D B Boyle, and
B E Coupar, and
D Reddy, and
A R Bellamy, and
G W Both
January 2006,
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,
M E Andrew, and
D B Boyle, and
B E Coupar, and
D Reddy, and
A R Bellamy, and
G W Both
October 1998,
Virology,
M E Andrew, and
D B Boyle, and
B E Coupar, and
D Reddy, and
A R Bellamy, and
G W Both
June 2001,
Indian journal of experimental biology,
M E Andrew, and
D B Boyle, and
B E Coupar, and
D Reddy, and
A R Bellamy, and
G W Both
December 2013,
Virus research,
M E Andrew, and
D B Boyle, and
B E Coupar, and
D Reddy, and
A R Bellamy, and
G W Both
June 2009,
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine],
M E Andrew, and
D B Boyle, and
B E Coupar, and
D Reddy, and
A R Bellamy, and
G W Both
October 1994,
Virology,
M E Andrew, and
D B Boyle, and
B E Coupar, and
D Reddy, and
A R Bellamy, and
G W Both
June 2009,
Vaccine,
M E Andrew, and
D B Boyle, and
B E Coupar, and
D Reddy, and
A R Bellamy, and
G W Both
February 2011,
Virology,
M E Andrew, and
D B Boyle, and
B E Coupar, and
D Reddy, and
A R Bellamy, and
G W Both
February 2006,
Proceedings of the National Academy of Sciences of the United States of America,
