-transparent.png){kind=logo}
A series of O-methylazithromycin derivatives have been synthesized and their antibacterial activities were compared with those of azithromycin (1). O-Methylation of 1 proceeded stepwise by the two main pathways beginning at the C-6 and C-11 hydroxyl groups, individually. Among O-methyl derivatives, 6-O-methylazithromycin A (11) was slightly less active than 1. The methylation of the secondary hydroxyl group at the C-11 position resulted surprisingly in an increase of their in vitro activity. The antibacterial activities of novel azalides decreased with increasing the number of the methyl groups introduced.
Related Publications
G Kobrehel, and
G Lazarevski, and
S Dokić, and
L Kolacny-Babić, and
N Kucisec-Iepes, and
M Cvrlje
July 2004,
Bioorganic & medicinal chemistry letters,
G Kobrehel, and
G Lazarevski, and
S Dokić, and
L Kolacny-Babić, and
N Kucisec-Iepes, and
M Cvrlje
February 2017,
European journal of medicinal chemistry,
G Kobrehel, and
G Lazarevski, and
S Dokić, and
L Kolacny-Babić, and
N Kucisec-Iepes, and
M Cvrlje
October 2008,
Bioorganic & medicinal chemistry letters,
G Kobrehel, and
G Lazarevski, and
S Dokić, and
L Kolacny-Babić, and
N Kucisec-Iepes, and
M Cvrlje
June 2007,
Bioorganic & medicinal chemistry letters,
G Kobrehel, and
G Lazarevski, and
S Dokić, and
L Kolacny-Babić, and
N Kucisec-Iepes, and
M Cvrlje
July 2011,
European journal of medicinal chemistry,
G Kobrehel, and
G Lazarevski, and
S Dokić, and
L Kolacny-Babić, and
N Kucisec-Iepes, and
M Cvrlje
February 2006,
Bioorganic & medicinal chemistry letters,
G Kobrehel, and
G Lazarevski, and
S Dokić, and
L Kolacny-Babić, and
N Kucisec-Iepes, and
M Cvrlje
March 2009,
Bioorganic & medicinal chemistry letters,
G Kobrehel, and
G Lazarevski, and
S Dokić, and
L Kolacny-Babić, and
N Kucisec-Iepes, and
M Cvrlje
April 2000,
Bioorganic & medicinal chemistry letters,
G Kobrehel, and
G Lazarevski, and
S Dokić, and
L Kolacny-Babić, and
N Kucisec-Iepes, and
M Cvrlje
October 2009,
Journal of Asian natural products research,
G Kobrehel, and
G Lazarevski, and
S Dokić, and
L Kolacny-Babić, and
N Kucisec-Iepes, and
M Cvrlje
August 2010,
Archiv der Pharmazie,
