BIOMAT Database Logo BIOMAT Database Logo

Adipose tissue lipolysis after long-term overfeeding in identical twins. 1992

P Mauriège, and J P Després, and M Marcotte, and A Tremblay, and A Nadeau, and S Moorjani, and P Lupien, and J Dussault, and G Fournier, and G Thériault
Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Québec, Canada.

Ten pairs of young male sedentary, non-obese, monozygotic (MZ) twins, aged 21 +/- 2 years (mean +/- s.d.), were overfed for a period of 100 days during which they ingested 4.2 MJ (1000 kcal) per day above their individual energy needs, 6 days per week. There was a mean 8.4 kg increase in body weight and the average gain in body fat reaches 5.6 kg (P less than 0.0001). A biopsy of subcutaneous abdominal fat was performed, before and after the treatment, to determine fat cell weight as well as basal and catecholamine stimulated lipolyses from collagenase isolated adipocytes. Although analysis of variance revealed an increase in abdominal fat cell weight, no significant changes were noted in basal and catecholamine-stimulated lipolyses, due to large variation among individuals, results being expressed either per cell number or corrected for cell surface area. However, significant intrapair resemblance was observed in the changes of basal and epinephrine stimulated lipolyses (ri of about 0.60 in both cases), suggesting a concordant within-pair response, despite large between-pair variation. These results support the notion that the genotype may play an important role in regulating the response of abdominal adipose cells lipolytic activity to caloric excess.

UI MeSH Term Description Entries
D006963 Hyperphagia Ingestion of a greater than optimal quantity of food. Overeating,Polyphagia,Polyphagias
D007545 Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant. Isoprenaline,Isopropylarterenol,4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol,Euspiran,Isadrin,Isadrine,Isopropyl Noradrenaline,Isopropylnoradrenaline,Isopropylnorepinephrine,Isoproterenol Hydrochloride,Isoproterenol Sulfate,Isuprel,Izadrin,Norisodrine,Novodrin,Hydrochloride, Isoproterenol,Noradrenaline, Isopropyl,Sulfate, Isoproterenol
D008019 Life Style Typical way of life or manner of living characteristic of an individual or group. (From APA, Thesaurus of Psychological Index Terms, 8th ed) Lifestyle Factors,Life Style Induced Illness,Lifestyle,Factor, Lifestyle,Life Styles,Lifestyle Factor,Lifestyles
D008066 Lipolysis The metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues. Lipolyses
D008297 Male Males
D009765 Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D004837 Epinephrine The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS. Adrenaline,4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol,Adrenaline Acid Tartrate,Adrenaline Bitartrate,Adrenaline Hydrochloride,Epifrin,Epinephrine Acetate,Epinephrine Bitartrate,Epinephrine Hydrochloride,Epinephrine Hydrogen Tartrate,Epitrate,Lyophrin,Medihaler-Epi,Acetate, Epinephrine
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000005 Abdomen That portion of the body that lies between the THORAX and the PELVIS. Abdomens
D000273 Adipose Tissue Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white. Fatty Tissue,Body Fat,Fat Pad,Fat Pads,Pad, Fat,Pads, Fat,Tissue, Adipose,Tissue, Fatty

Related Publications

P Mauriège, and J P Després, and M Marcotte, and A Tremblay, and A Nadeau, and S Moorjani, and P Lupien, and J Dussault, and G Fournier, and G Thériault
The response to long-term overfeeding in identical twins.
May 1990, The New England journal of medicine,
P Mauriège, and J P Després, and M Marcotte, and A Tremblay, and A Nadeau, and S Moorjani, and P Lupien, and J Dussault, and G Fournier, and G Thériault
Plasma glucose, insulin, and glucagon before and after long-term overfeeding in identical twins.
January 1995, Metabolism: clinical and experimental,
P Mauriège, and J P Després, and M Marcotte, and A Tremblay, and A Nadeau, and S Moorjani, and P Lupien, and J Dussault, and G Fournier, and G Thériault
Effects of long-term overfeeding on plasma lipoprotein levels in identical twins.
April 2004, Atherosclerosis,
P Mauriège, and J P Després, and M Marcotte, and A Tremblay, and A Nadeau, and S Moorjani, and P Lupien, and J Dussault, and G Fournier, and G Thériault
Thyroid hormones and thyrotropin variations during long term overfeeding in identical twins.
August 1994, The Journal of clinical endocrinology and metabolism,
P Mauriège, and J P Després, and M Marcotte, and A Tremblay, and A Nadeau, and S Moorjani, and P Lupien, and J Dussault, and G Fournier, and G Thériault
Plasma adrenal, gonadal, and conjugated steroids before and after long-term overfeeding in identical twins.
September 1998, The Journal of clinical endocrinology and metabolism,
P Mauriège, and J P Després, and M Marcotte, and A Tremblay, and A Nadeau, and S Moorjani, and P Lupien, and J Dussault, and G Fournier, and G Thériault
Short term voluntary overfeeding disrupts brain insulin control of adipose tissue lipolysis.
September 2012, The Journal of biological chemistry,
P Mauriège, and J P Després, and M Marcotte, and A Tremblay, and A Nadeau, and S Moorjani, and P Lupien, and J Dussault, and G Fournier, and G Thériault
Long-term pioglitazone treatment enhances lipolysis in rat adipose tissue.
December 2008, International journal of obesity (2005),
P Mauriège, and J P Després, and M Marcotte, and A Tremblay, and A Nadeau, and S Moorjani, and P Lupien, and J Dussault, and G Fournier, and G Thériault
Overfeeding in identical twins: 5-year postoverfeeding results.
August 1996, Metabolism: clinical and experimental,
P Mauriège, and J P Després, and M Marcotte, and A Tremblay, and A Nadeau, and S Moorjani, and P Lupien, and J Dussault, and G Fournier, and G Thériault
Genotype dependency of adaptation in adipose tissue metabolism after short-term overfeeding.
April 1986, The American journal of physiology,
P Mauriège, and J P Després, and M Marcotte, and A Tremblay, and A Nadeau, and S Moorjani, and P Lupien, and J Dussault, and G Fournier, and G Thériault
Adipose tissue lipolysis and hormone-sensitive lipase expression during very-low-calorie diet in obese female identical twins.
March 1997, The Journal of clinical endocrinology and metabolism,
Copied contents to your clipboard!