-transparent.png){kind=logo}
Proton pump inhibitors have been reported to have a cytoprotective action in addition to the anti-secretory action of acid. The precise mechanism, however, remains obscure. In this study, the effects of proton pump inhibitors (omeprazole and NC-1300) on gastric mucosa hemodynamics and tissue oxygenation were investigated using organ reflectance spectrophotometry in a hemorrhagic shock-reperfusion model involving anesthetized rats. Neither drug affected gastric mucosa hemodynamics nor tissue oxygenation in the basal state before hemorrhage. During the hemorrhagic shock state, however, these drugs maintained tissue oxygenation and reduced ulcer formation, although they did not show a significant effect on gastric mucosa blood volume. The results suggest that both proton pump inhibitors have an anti-ulcer action by maintaining mucosal oxygenation in addition to the anti-secretory activity of acid.
S Kawano, and
H Tanimura, and
N Sato, and
S Tsuji, and
Y Takei, and
T Ogihara, and
K Nagano, and
H Fusamoto, and
T Kamada
January 1992,
Nihon rinsho. Japanese journal of clinical medicine,
S Kawano, and
H Tanimura, and
N Sato, and
S Tsuji, and
Y Takei, and
T Ogihara, and
K Nagano, and
H Fusamoto, and
T Kamada
July 2018,
Journal of the Chinese Medical Association : JCMA,
S Kawano, and
H Tanimura, and
N Sato, and
S Tsuji, and
Y Takei, and
T Ogihara, and
K Nagano, and
H Fusamoto, and
T Kamada
March 1998,
Japanese journal of pharmacology,
S Kawano, and
H Tanimura, and
N Sato, and
S Tsuji, and
Y Takei, and
T Ogihara, and
K Nagano, and
H Fusamoto, and
T Kamada
May 1984,
Digestive diseases and sciences,
S Kawano, and
H Tanimura, and
N Sato, and
S Tsuji, and
Y Takei, and
T Ogihara, and
K Nagano, and
H Fusamoto, and
T Kamada
July 1989,
Digestive diseases and sciences,
S Kawano, and
H Tanimura, and
N Sato, and
S Tsuji, and
Y Takei, and
T Ogihara, and
K Nagano, and
H Fusamoto, and
T Kamada
November 2016,
Applied and environmental microbiology,
S Kawano, and
H Tanimura, and
N Sato, and
S Tsuji, and
Y Takei, and
T Ogihara, and
K Nagano, and
H Fusamoto, and
T Kamada
January 2024,
Clinical endoscopy,
S Kawano, and
H Tanimura, and
N Sato, and
S Tsuji, and
Y Takei, and
T Ogihara, and
K Nagano, and
H Fusamoto, and
T Kamada
January 1988,
La Revue de medecine interne,
S Kawano, and
H Tanimura, and
N Sato, and
S Tsuji, and
Y Takei, and
T Ogihara, and
K Nagano, and
H Fusamoto, and
T Kamada
January 1989,
Scandinavian journal of gastroenterology. Supplement,
S Kawano, and
H Tanimura, and
N Sato, and
S Tsuji, and
Y Takei, and
T Ogihara, and
K Nagano, and
H Fusamoto, and
T Kamada
April 1993,
Japanese journal of pharmacology,
