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High-dose epirubicin in chemotherapy refractory non-seminomatous germ cell cancer: a phase II study. EORTC Genito-Urinary Tract Cancer Co-operative Group. EORTC Early Clinical Trials Group. 1992
G Stoter, and
A Akdas, and
S D Fosså, and
S B Kaye, and
C J van Groeningen, and
J Renard, and
M van Glabbeke
Department of Medical Oncology, Rotterdam Cancer Institute, The Netherlands.
Eighteen patients with progressive disseminated, platinum-resistant germ cell tumors were treated with epirubicin 135 mg/m2, every 3 weeks. One patient had stable disease, 17 developed progression. Myelosuppression was dose-limiting. One patient died of neutropenic septicemia. High-dose epirubicin is not active against platinum-resistant germ cell cancer.
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