-transparent.png){kind=logo}
We demonstrate that the cells of the sponge Geodia cydonium are equipped with the basic elements required for a retinoic acid (RA)-dependent response pathway; RA was identified and quantitated, the cellular RA-binding protein (CRABP) was detected and the nuclear RA receptor (RAR) was found. In the isolated cell system the level of CRABP, but not of RAR, is strongly induced after incubating the cells for 10h with the homologous aggregation factor. In induced cells incubation with 0.3 microM RA results in a strong down-regulation of the c-myb (or c-myb-related) proto-oncogene (M(r) 63,000; mRNA 3.3 kb). We postulate that this pathway is also functionally active and that RA acts as a natural morphogen.
H K Biesalski, and
G Doepner, and
G Tzimas, and
V Gamulin, and
H C Schröder, and
R Batel, and
H Nau, and
W E Müller
January 1992,
Pathobiology : journal of immunopathology, molecular and cellular biology,
H K Biesalski, and
G Doepner, and
G Tzimas, and
V Gamulin, and
H C Schröder, and
R Batel, and
H Nau, and
W E Müller
June 1996,
Biochemical and biophysical research communications,
H K Biesalski, and
G Doepner, and
G Tzimas, and
V Gamulin, and
H C Schröder, and
R Batel, and
H Nau, and
W E Müller
November 2002,
Journal of lipid research,
H K Biesalski, and
G Doepner, and
G Tzimas, and
V Gamulin, and
H C Schröder, and
R Batel, and
H Nau, and
W E Müller
April 1997,
The Journal of biological chemistry,
H K Biesalski, and
G Doepner, and
G Tzimas, and
V Gamulin, and
H C Schröder, and
R Batel, and
H Nau, and
W E Müller
September 2009,
The Journal of biological chemistry,
H K Biesalski, and
G Doepner, and
G Tzimas, and
V Gamulin, and
H C Schröder, and
R Batel, and
H Nau, and
W E Müller
September 1990,
Nutrition reviews,
H K Biesalski, and
G Doepner, and
G Tzimas, and
V Gamulin, and
H C Schröder, and
R Batel, and
H Nau, and
W E Müller
November 1991,
DNA and cell biology,
H K Biesalski, and
G Doepner, and
G Tzimas, and
V Gamulin, and
H C Schröder, and
R Batel, and
H Nau, and
W E Müller
May 1995,
Molecular and cellular biology,
H K Biesalski, and
G Doepner, and
G Tzimas, and
V Gamulin, and
H C Schröder, and
R Batel, and
H Nau, and
W E Müller
April 2004,
Diabetes,
H K Biesalski, and
G Doepner, and
G Tzimas, and
V Gamulin, and
H C Schröder, and
R Batel, and
H Nau, and
W E Müller
April 1992,
Molecular endocrinology (Baltimore, Md.),
