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Platelet homogenates from 200 ml blood of essential hypertensives (n = 28) and normotensives (n = 13) were deproteinized and separated by gel chromatography. The fractions obtained were then tested for vasopressor activity in the isolated perfused rat kidney. In both normotensives and hypertensives, two vasopressor fractions appeared. There was no difference in vasopressor activity in the first vasoactive fraction between normotensives and hypertensives. In the second vasoactive fraction, the hypertensive patients showed a significant higher activity than the normotensive subjects (increase in perfusion pressure by 35.9 +/- 11.5 vs. 6.8 +/- 5.3 mmHg, p less than 0.01). This vasopressor fraction was not inhibited by saralasin, phentolamine, ketanserin, nitroprusside and daltroban and was effective after pretreatment with indomethacin and reserpine and in enzymatically deendothelialized kidneys. The effect was reduced by nifedipine and unchanged by heating the fraction at 100 degrees C and by incubation with proteinase K. It is concluded that a yet unidentified platelet-derived vasopressor agent may contribute to the enhanced vasoconstriction in essential hypertension.
A Agha, and
H Schlüter, and
S König, and
K Biel, and
M Tepel, and
W Zidek
December 1989,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
A Agha, and
H Schlüter, and
S König, and
K Biel, and
M Tepel, and
W Zidek
June 1990,
The American journal of physiology,
A Agha, and
H Schlüter, and
S König, and
K Biel, and
M Tepel, and
W Zidek
May 1999,
Clinica chimica acta; international journal of clinical chemistry,
A Agha, and
H Schlüter, and
S König, and
K Biel, and
M Tepel, and
W Zidek
April 2002,
American journal of hypertension,
A Agha, and
H Schlüter, and
S König, and
K Biel, and
M Tepel, and
W Zidek
December 1995,
Hypertension research : official journal of the Japanese Society of Hypertension,
A Agha, and
H Schlüter, and
S König, and
K Biel, and
M Tepel, and
W Zidek
July 1988,
American journal of optometry and physiological optics,
A Agha, and
H Schlüter, and
S König, and
K Biel, and
M Tepel, and
W Zidek
December 1976,
Lancet (London, England),
A Agha, and
H Schlüter, and
S König, and
K Biel, and
M Tepel, and
W Zidek
October 1972,
The Journal of pathology,
A Agha, and
H Schlüter, and
S König, and
K Biel, and
M Tepel, and
W Zidek
September 1998,
American journal of hypertension,
A Agha, and
H Schlüter, and
S König, and
K Biel, and
M Tepel, and
W Zidek
September 1991,
Journal of hypertension,
