Genetic relationships between bovine herpesvirus 4 and the gammaherpesviruses Epstein-Barr virus and herpesvirus saimiri. 1992

M Bublot, and P Lomonte, and A S Lequarre, and J C Albrecht, and J Nicholas, and B Fleckenstein, and P P Pastoret, and E Thiry
Virology Department, Faculty of Veterinary Medicine, University of Liège, Belgium.

The overall arrangement of genes in the unique central part of the bovine herpesvirus type 4 (BHV-4) genome has been deduced by analysis of short DNA sequences. Twenty-three genes conserved in at least one of the completely sequenced herpesviruses have been identified and localized. All of these genes encoded amino acid sequences with higher similarity to proteins of the gammaherpesviruses Epstein-Barr virus (EBV) and herpesvirus saimiri (HVS) than to the homologous products of the alphaherpesviruses varicella-zoster virus and herpes simplex virus type 1 or the betaherpesvirus human cytomegalovirus. The genome organization of BHV-4 had also an overall colinearity with that of the gammaherpesviruses EBV and HVS. Furthermore, the BHV-4 genes content and arrangement were more similar to those of HVS than to those of EBV, suggesting that BHV-4 and HVS are evolutionarily more closely related to each other than either are to EBV. BHV-4 DNA sequences were generally deficient in CpG dinucleotide. This CpG deficiency is characteristic of gammaherpesvirus genomes and suggests that the BHV-4 latent genome is extensively methylated. Despite several biological features similar to those of betaherpesviruses, BHV-4 displays the molecular characteristics of the representative members of the gammaherpesvirinae subfamily.

UI MeSH Term Description Entries
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D010957 Plasmids Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS. Episomes,Episome,Plasmid
D003001 Cloning, Molecular The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells. Molecular Cloning
D004854 Herpesvirus 4, Human The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies. Burkitt Herpesvirus,Burkitt Lymphoma Virus,E-B Virus,EBV,Epstein-Barr Virus,Human Herpesvirus 4,Infectious Mononucleosis Virus,Burkitt's Lymphoma Virus,HHV-4,Herpesvirus 4 (gamma), Human,Burkitts Lymphoma Virus,E B Virus,E-B Viruses,Epstein Barr Virus,Herpesvirus, Burkitt,Infectious Mononucleosis Viruses,Lymphoma Virus, Burkitt,Mononucleosis Virus, Infectious,Mononucleosis Viruses, Infectious
D005814 Genes, Viral The functional hereditary units of VIRUSES. Viral Genes,Gene, Viral,Viral Gene
D006564 Herpesviridae A family of enveloped, linear, double-stranded DNA viruses infecting a wide variety of animals. Subfamilies, based on biological characteristics, include: ALPHAHERPESVIRINAE; BETAHERPESVIRINAE; and GAMMAHERPESVIRINAE. Mouse Thymic Virus,Murid herpesvirus 3,Thymic Group Viruses,Herpesviruses,Mouse Thymic Viruses,Thymic Virus, Mouse,Thymic Viruses, Mouse
D006567 Herpesvirus 2, Saimiriine The type species of RHADINOVIRUS, in the subfamily GAMMAHERPESVIRINAE, isolated from squirrel monkeys. It produces malignant lymphomas (LYMPHOMA, MALIGNANT) in inoculated marmosets or owl monkeys. Herpesvirus 2, Saimirine,Herpesvirus 2 (gamma), Saimirine,Herpesvirus Saimiri,Saimiriine Herpesvirus 2,Saimirine Herpesvirus 2,Herpesvirus Saimirus,Saimiri, Herpesvirus,Saimirus, Herpesvirus
D000595 Amino Acid Sequence The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION. Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein
D012689 Sequence Homology, Nucleic Acid The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function. Base Sequence Homology,Homologous Sequences, Nucleic Acid,Homologs, Nucleic Acid Sequence,Homology, Base Sequence,Homology, Nucleic Acid Sequence,Nucleic Acid Sequence Homologs,Nucleic Acid Sequence Homology,Sequence Homology, Base,Base Sequence Homologies,Homologies, Base Sequence,Sequence Homologies, Base
D014764 Viral Proteins Proteins found in any species of virus. Gene Products, Viral,Viral Gene Products,Viral Gene Proteins,Viral Protein,Protein, Viral,Proteins, Viral

Related Publications

M Bublot, and P Lomonte, and A S Lequarre, and J C Albrecht, and J Nicholas, and B Fleckenstein, and P P Pastoret, and E Thiry
June 1990, The Journal of general virology,
M Bublot, and P Lomonte, and A S Lequarre, and J C Albrecht, and J Nicholas, and B Fleckenstein, and P P Pastoret, and E Thiry
August 1977, The Journal of general virology,
M Bublot, and P Lomonte, and A S Lequarre, and J C Albrecht, and J Nicholas, and B Fleckenstein, and P P Pastoret, and E Thiry
January 1973, Bibliotheca haematologica,
M Bublot, and P Lomonte, and A S Lequarre, and J C Albrecht, and J Nicholas, and B Fleckenstein, and P P Pastoret, and E Thiry
June 1981, Journal of the National Cancer Institute,
M Bublot, and P Lomonte, and A S Lequarre, and J C Albrecht, and J Nicholas, and B Fleckenstein, and P P Pastoret, and E Thiry
February 1978, Biomedicine / [publiee pour l'A.A.I.C.I.G.],
M Bublot, and P Lomonte, and A S Lequarre, and J C Albrecht, and J Nicholas, and B Fleckenstein, and P P Pastoret, and E Thiry
January 2019, Frontiers in microbiology,
M Bublot, and P Lomonte, and A S Lequarre, and J C Albrecht, and J Nicholas, and B Fleckenstein, and P P Pastoret, and E Thiry
March 1988, Journal of virology,
M Bublot, and P Lomonte, and A S Lequarre, and J C Albrecht, and J Nicholas, and B Fleckenstein, and P P Pastoret, and E Thiry
January 2001, Advances in cancer research,
M Bublot, and P Lomonte, and A S Lequarre, and J C Albrecht, and J Nicholas, and B Fleckenstein, and P P Pastoret, and E Thiry
January 1983, Intervirology,
M Bublot, and P Lomonte, and A S Lequarre, and J C Albrecht, and J Nicholas, and B Fleckenstein, and P P Pastoret, and E Thiry
April 1981, Virology,
Copied contents to your clipboard!