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Myeloperoxidase was solubilized with hexadecyltrimethylammonium bromide and myeloperoxidase activity was measured with a dianisidine-H2O2 assay in the ischemic area after middle cerebral artery occlusion in rats. This enzyme could be measured 6 hours after the occlusion of the middle cerebral artery, then showed two peaks, one after 8 hours and another after 18 to 24 hours in 2 phase fashion as could be measured as far as 7 days, which was the termination of this experiments. These findings suggest that leukocyte infiltration into the ischemic area play an important role for the extension of the ischemic area. Further study should undertake whether leukocyte depletion decrease the ischemic area or not.
T Kawano, and
K Hirata, and
T Toba, and
K Mori
July 1991,
Journal of neuroscience research,
T Kawano, and
K Hirata, and
T Toba, and
K Mori
October 2010,
Acta cirurgica brasileira,
T Kawano, and
K Hirata, and
T Toba, and
K Mori
November 1987,
Journal of neurology, neurosurgery, and psychiatry,
T Kawano, and
K Hirata, and
T Toba, and
K Mori
February 2018,
Molecular medicine reports,
T Kawano, and
K Hirata, and
T Toba, and
K Mori
July 2002,
Hypertension research : official journal of the Japanese Society of Hypertension,
T Kawano, and
K Hirata, and
T Toba, and
K Mori
November 1985,
Journal of pharmacological methods,
T Kawano, and
K Hirata, and
T Toba, and
K Mori
December 2003,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
T Kawano, and
K Hirata, and
T Toba, and
K Mori
September 2006,
Age (Dordrecht, Netherlands),
T Kawano, and
K Hirata, and
T Toba, and
K Mori
October 2002,
Stroke,
T Kawano, and
K Hirata, and
T Toba, and
K Mori
January 1992,
Experimental brain research,
