Biomaterial Database

Studies on the compatibility of diethylpropion hydrochloride with carboxymethylcellulose and other dietary fibres. 1992

P J Retuert, and M Yazdani-Pedram

Departmento de Quimica, Facultad Ciencias Fis. Y Mat., Universidad de Chile, Santiago.

The combination of diethylpropion hydrochloride with carboxymethylcellulose induces decomposition of the drug. The principal decomposition products obtained were 1-phenyl-1,2-propanedione, benzoic acid and diethylamine as hydrochloride and benzoate salts. These phenomena have been explained with reference to basic decomposition scheme of the diethylpropion. Additionally, the behaviour of diethylpropion in mixtures with other dietary fibres such as methylcellulose, wheat bran and wheat germ was examined. Diethylpropion in combination with methylcellulose is rather stable while in mixtures with wheat bran and wheat germ suffers degradation. An increase in the weight of the excipient, probably due to chemical binding of the drug and other degradation products by the excipient, was observed in all these cases. The decomposition reactions were studied by applying a sequence of selective solvent extractions and using high-performance liquid chromatography (HPLC).

UI	MeSH Term	Description	Entries
D002266	Carboxymethylcellulose Sodium	A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.	Carboxymethyl Cellulose,Carboxymethylcellulose,Aquacel,Aquaplast,Carmellose Sodium,Cellolax,Cethylose,Croscarmellose Sodium,Polycell,Ruspol,Sodium Carboxymethylcellulose,Carboxymethylcellulose, Sodium,Cellulose, Carboxymethyl,Sodium, Carboxymethylcellulose,Sodium, Carmellose,Sodium, Croscarmellose
D002626	Chemistry, Pharmaceutical	Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.	Medicinal Chemistry,Chemistry, Pharmaceutic,Pharmaceutic Chemistry,Pharmaceutical Chemistry,Chemistry, Medicinal
D002627	Chemistry, Physical	The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes.	Physical Chemistry,Chemistries, Physical,Physical Chemistries
D004043	Dietary Fiber	The remnants of plant cell walls that are resistant to digestion by the alimentary enzymes of man. It comprises various polysaccharides and lignins.	Fiber, Dietary,Roughage,Wheat Bran,Bran, Wheat,Brans, Wheat,Dietary Fibers,Fibers, Dietary,Roughages,Wheat Brans
D004053	Diethylpropion	A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)	Amfepramon,2-Diethylaminopropiophenone,Amfepramone,Anorex,Delgamer,Diethylpropion Hydrochloride,Dietil-retard,Ifa Norex,Lipomin,Maruate,Modératan,Neobes,Nobesine,Phepranon,Propion,Préfamone,Regenon,Regibon,Tenuate,Tepanil,Dietil retard,Dietilretard,Hydrochloride, Diethylpropion,Norex, Ifa
D013607	Tablets	Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)	Tablet
D014908	Triticum	A plant genus of the family POACEAE that is the source of EDIBLE GRAIN. A hybrid with rye (SECALE CEREALE) is called TRITICALE. The seed is ground into FLOUR and used to make BREAD, and is the source of WHEAT GERM AGGLUTININS.	Wheat,Durum Wheat,Triticum aestivum,Triticum durum,Triticum spelta,Triticum turgidum,Triticum turgidum subsp. durum,Triticum vulgare,Durum Wheats,Wheat, Durum
D055598	Chemical Phenomena	The composition, structure, conformation, and properties of atoms and molecules, and their reaction and interaction processes.	Chemical Concepts,Chemical Processes,Physical Chemistry Concepts,Physical Chemistry Processes,Physicochemical Concepts,Physicochemical Phenomena,Physicochemical Processes,Chemical Phenomenon,Chemical Process,Physical Chemistry Phenomena,Physical Chemistry Process,Physicochemical Phenomenon,Physicochemical Process,Chemical Concept,Chemistry Process, Physical,Chemistry Processes, Physical,Concept, Chemical,Concept, Physical Chemistry,Concept, Physicochemical,Concepts, Chemical,Concepts, Physical Chemistry,Concepts, Physicochemical,Phenomena, Chemical,Phenomena, Physical Chemistry,Phenomena, Physicochemical,Phenomenon, Chemical,Phenomenon, Physicochemical,Physical Chemistry Concept,Physicochemical Concept,Process, Chemical,Process, Physical Chemistry,Process, Physicochemical,Processes, Chemical,Processes, Physical Chemistry,Processes, Physicochemical