-transparent.png){kind=logo}
Since the beginning of the clinical use of low molecular weight (LMW) heparins their thrombolytic or profibrinolytic potency has been a matter of controversial discussions. Regarding this problem, the aim of our study was to test a LMW-heparin (Sandoparin) in an in vivo model comparing its lytic activity to unfractionated heparin and urokinase at different doses. For this purpose a newly developed short-term rabbit jugular vein clot lysis model was developed. Urokinase infused at doses of 3300, 6600 and 10,000 U/kg to control animals for one hour showed a clear dose-dependent clot lysis. Test animals were injected with a bolus of 0.5 mg/kg of LMW-heparin followed by a constant infusion of either 0.5, 1.0 or 2.0 mg/kg for one hour. A similar dose-dependent effect was observed for LMW-heparin as for urokinase. Unfractionated heparin did not exhibit a dose-dependent lytic activity in this model. No lysis was found in rabbits treated with saline. These findings suggest that the LMW-heparin tested exhibits a dose-dependent in vivo lytic activity which can be compared to clinically effective doses of urokinase, and that this activity is not present with unfractionated heparin.
P Bacher, and
D Welzel, and
O Iqbal, and
D Hoppensteadt, and
D Callas, and
J M Walenga, and
J Fareed
April 1986,
Thrombosis research,
P Bacher, and
D Welzel, and
O Iqbal, and
D Hoppensteadt, and
D Callas, and
J M Walenga, and
J Fareed
October 2001,
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
P Bacher, and
D Welzel, and
O Iqbal, and
D Hoppensteadt, and
D Callas, and
J M Walenga, and
J Fareed
October 1986,
Neurosurgery,
P Bacher, and
D Welzel, and
O Iqbal, and
D Hoppensteadt, and
D Callas, and
J M Walenga, and
J Fareed
April 1985,
Journal of neurosurgery,
P Bacher, and
D Welzel, and
O Iqbal, and
D Hoppensteadt, and
D Callas, and
J M Walenga, and
J Fareed
September 2006,
Thrombosis journal,
P Bacher, and
D Welzel, and
O Iqbal, and
D Hoppensteadt, and
D Callas, and
J M Walenga, and
J Fareed
January 1976,
Haemostasis,
P Bacher, and
D Welzel, and
O Iqbal, and
D Hoppensteadt, and
D Callas, and
J M Walenga, and
J Fareed
April 1993,
Thrombosis and haemostasis,
P Bacher, and
D Welzel, and
O Iqbal, and
D Hoppensteadt, and
D Callas, and
J M Walenga, and
J Fareed
October 1986,
Neurosurgery,
P Bacher, and
D Welzel, and
O Iqbal, and
D Hoppensteadt, and
D Callas, and
J M Walenga, and
J Fareed
October 1986,
Neurosurgery,
P Bacher, and
D Welzel, and
O Iqbal, and
D Hoppensteadt, and
D Callas, and
J M Walenga, and
J Fareed
August 1984,
Thrombosis and haemostasis,
