Biomaterial Database

[Mechanism of renal vein thrombosis in patients with nephrotic syndrome: a prospective study]. 1992

H Cheng

First Hospital, Beijing Medical University.

One hundred nephrotic patients were routinely examined with renal venography and renal biopsy. Blood platelet (BPC), aggregation (Pag), adhesiveness (Pad), kaolin prothrombin time (KPTT), thrombin time (TT), plasma viscosity (PV) were tested in 50 patients. Also plasma fibrinogen (Fbg), fibrin/fibrinogen degradation product (FDP), antithrombin III (AT III), antiplasmin (PI), plasminogen (Plg) were investigated from the peripheral vein, superior, inferior veno cava, and right, left renal vein. Forty-six nephrotic patients had the complication of renal vein thrombosis (RVT); 4/5 of them were clinically latent. Multivariate regression analysis, showed that the number of 2 renal branches with RVT (RVTn) related to the history of steroid and membranopathy was associated with the tendency of RVT formation. Coagulation-fibrinolysis test showed RVTn = 1.17284 Pag-0.02363 PI + 0.04034 AT III + 3.21141 PV-0.02447 Plg + 2.33538 (P = 0.025). Fbg in renal vein involved with RVT was significantly different from the innocent side (P < 0.05). In addition, correlations were found between AT III and protein in urine (P < 0.01) and between plasma Fbg and albumin (P < 0.02). 46% patients with nephrotic syndrome complicated by RVT were usually clinically latent. Disorders of platelet function, increased PV, steroid and intensive diuretic treatment might promote RVT formation, especially in membranopathy.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009404	Nephrotic Syndrome	A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.	Childhood Idiopathic Nephrotic Syndrome,Frequently Relapsing Nephrotic Syndrome,Multi-Drug Resistant Nephrotic Syndrome,Pediatric Idiopathic Nephrotic Syndrome,Steroid-Dependent Nephrotic Syndrome,Steroid-Resistant Nephrotic Syndrome,Steroid-Sensitive Nephrotic Syndrome,Multi Drug Resistant Nephrotic Syndrome,Nephrotic Syndrome, Steroid-Dependent,Nephrotic Syndrome, Steroid-Resistant,Nephrotic Syndrome, Steroid-Sensitive,Nephrotic Syndromes,Steroid Dependent Nephrotic Syndrome,Steroid Resistant Nephrotic Syndrome,Steroid Sensitive Nephrotic Syndrome,Steroid-Dependent Nephrotic Syndromes,Steroid-Resistant Nephrotic Syndromes,Steroid-Sensitive Nephrotic Syndromes,Syndrome, Nephrotic,Syndrome, Steroid-Sensitive Nephrotic
D011241	Prednisone	A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.	Dehydrocortisone,delta-Cortisone,Apo-Prednisone,Cortan,Cortancyl,Cutason,Dacortin,Decortin,Decortisyl,Deltasone,Encorton,Encortone,Enkortolon,Kortancyl,Liquid Pred,Meticorten,Orasone,Panafcort,Panasol,Predni Tablinen,Prednidib,Predniment,Prednison Acsis,Prednison Galen,Prednison Hexal,Pronisone,Rectodelt,Sone,Sterapred,Ultracorten,Winpred,Acsis, Prednison
D011446	Prospective Studies	Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.	Prospective Study,Studies, Prospective,Study, Prospective
D012082	Renal Veins	Short thick veins which return blood from the kidneys to the vena cava.	Renal Vein,Vein, Renal,Veins, Renal
D001780	Blood Coagulation Tests	Laboratory tests for evaluating the individual's clotting mechanism.	Coagulation Tests, Blood,Tests, Blood Coagulation,Blood Coagulation Test,Coagulation Test, Blood,Test, Blood Coagulation
D001809	Blood Viscosity	The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.	Blood Viscosities,Viscosities, Blood,Viscosity, Blood
D005260	Female		Females
D005665	Furosemide	A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.	Frusemide,Fursemide,Errolon,Frusemid,Furanthril,Furantral,Furosemide Monohydrochloride,Furosemide Monosodium Salt,Fusid,Lasix
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man