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Quantitative autoradiographic analysis of beta-adrenergic binding sites was conducted in human postmortem hypothalamus using the radioligand 125I-pindolol. The focus was on the hypothalamic nuclei most clearly involved in corticotropin-releasing hormone (CRH) release, the PVN and SON. For comparison, the distribution of hypothalamic beta-adrenergic receptors was evaluated in the rat. A high level of beta-adrenergic receptor binding was found in the human paraventricular nucleus (PVN) and supraoptic nucleus (SON), but not in the rat. The majority of the beta-adrenergic receptors found in the human hypothalamus were of the beta 2-subtype. In contrast, in the rat hypothalamus, the majority of receptors were of the beta 1-subtype. These results show that the anatomical loci exist for direct beta-adrenergic influence on hypothalamic neuroendocrine function in the human and that the topography of beta-adrenergic receptors is markedly different in the rat and human hypothalamus.
K Y Little, and
G E Duncan, and
G R Breese, and
W E Stumpf
December 1993,
Endocrinology,
K Y Little, and
G E Duncan, and
G R Breese, and
W E Stumpf
August 1976,
Brain research,
K Y Little, and
G E Duncan, and
G R Breese, and
W E Stumpf
July 1977,
Canadian journal of biochemistry,
K Y Little, and
G E Duncan, and
G R Breese, and
W E Stumpf
August 1981,
European journal of pharmacology,
K Y Little, and
G E Duncan, and
G R Breese, and
W E Stumpf
January 1978,
Biochemical pharmacology,
K Y Little, and
G E Duncan, and
G R Breese, and
W E Stumpf
September 1983,
Brain research bulletin,
K Y Little, and
G E Duncan, and
G R Breese, and
W E Stumpf
January 1982,
Biochemical pharmacology,
K Y Little, and
G E Duncan, and
G R Breese, and
W E Stumpf
September 1974,
Acta pharmaceutica Suecica,
K Y Little, and
G E Duncan, and
G R Breese, and
W E Stumpf
September 1993,
American journal of obstetrics and gynecology,
K Y Little, and
G E Duncan, and
G R Breese, and
W E Stumpf
March 1982,
Science (New York, N.Y.),
