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To elucidate changes of adrenocortical steroid production with age, reproductive age (n = 14), peri-menopausal (n = 12) and post-menopausal (n = 13) women were studied using basal hormone levels and the results of a rapid ACTH stimulation test. Peripheral serum levels of pregnenolone, 17 alpha-hydroxypregnenolone, 17 alpha-hydroxyprogesterone, dehydroepiandrosterone and androstenedione were measured by RIA. The basal levels of all steroids except pregnenolone decreased with age. A significant increase in the levels of all steroids after ACTH stimulation was observed in all subjects. Although, there was an age related decrease in the response of C19-steroids to ACTH, the response of pregnenolone and 17 alpha-hydroxyprogesterone to ACTH did not alter with age. The preserved response of 17 alpha-hydroxyprogesterone to ACTH in post-menopausal women suggests that 17 alpha-hydroxyprogesterone production plays a role in the age independency of cortisol. In the present paper, the changes in the capacity of the post-menopausal adrenal cortex to produce androgens and C21-steroids were demonstrated.
T Akamatsu, and
H Chiba, and
H Kamiyama, and
K Hirose, and
H Saito, and
T Yanaihara
July 1980,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
T Akamatsu, and
H Chiba, and
H Kamiyama, and
K Hirose, and
H Saito, and
T Yanaihara
January 1968,
Revue francaise d'etudes cliniques et biologiques,
T Akamatsu, and
H Chiba, and
H Kamiyama, and
K Hirose, and
H Saito, and
T Yanaihara
May 1986,
Nihon Naibunpi Gakkai zasshi,
T Akamatsu, and
H Chiba, and
H Kamiyama, and
K Hirose, and
H Saito, and
T Yanaihara
January 1980,
Essays in biochemistry,
T Akamatsu, and
H Chiba, and
H Kamiyama, and
K Hirose, and
H Saito, and
T Yanaihara
July 1979,
Journal of steroid biochemistry,
T Akamatsu, and
H Chiba, and
H Kamiyama, and
K Hirose, and
H Saito, and
T Yanaihara
March 2008,
Aging cell,
T Akamatsu, and
H Chiba, and
H Kamiyama, and
K Hirose, and
H Saito, and
T Yanaihara
January 1995,
Ciba Foundation symposium,
T Akamatsu, and
H Chiba, and
H Kamiyama, and
K Hirose, and
H Saito, and
T Yanaihara
October 1953,
Surgical forum,
T Akamatsu, and
H Chiba, and
H Kamiyama, and
K Hirose, and
H Saito, and
T Yanaihara
September 2005,
Frontiers in bioscience : a journal and virtual library,
T Akamatsu, and
H Chiba, and
H Kamiyama, and
K Hirose, and
H Saito, and
T Yanaihara
May 2000,
Annals of the New York Academy of Sciences,
