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The effects of transforming growth factor-beta (TGF-beta) and ACTH on growth, as indicated by [3H]thymidine incorporation into DNA, of primary cultures of neocortical cells from the human fetal adrenal gland were studied. TGF-beta inhibited, in a dose- and time-dependent manner, the growth of fetal neocortical cells, and ACTH significantly blunted the inhibitory effects of TGF-beta on growth of these cells. ACTH did not block the inhibitory effects of TGF-beta on growth of fetal adrenal fibroblasts or liver cells; neither ACTH nor TGF-beta had any effect on growth of fetal kidney cells. Thus, it appears that growth regulation of the neocortex may differ strikingly from that of the fetal zone of the human fetal adrenal, in which ACTH and TGF-beta have been reported recently to have additive inhibitory effects on cell proliferation.
C R Parker, and
A K Stankovic, and
C Harlin, and
L Carden
April 1995,
Molecular and cellular endocrinology,
C R Parker, and
A K Stankovic, and
C Harlin, and
L Carden
October 1991,
Endocrinology,
C R Parker, and
A K Stankovic, and
C Harlin, and
L Carden
July 1987,
Science (New York, N.Y.),
C R Parker, and
A K Stankovic, and
C Harlin, and
L Carden
July 1997,
The Journal of biological chemistry,
C R Parker, and
A K Stankovic, and
C Harlin, and
L Carden
January 1993,
Growth factors (Chur, Switzerland),
C R Parker, and
A K Stankovic, and
C Harlin, and
L Carden
January 1998,
Steroids,
C R Parker, and
A K Stankovic, and
C Harlin, and
L Carden
June 1989,
Biochemical and biophysical research communications,
C R Parker, and
A K Stankovic, and
C Harlin, and
L Carden
September 1992,
The American journal of pathology,
C R Parker, and
A K Stankovic, and
C Harlin, and
L Carden
February 1999,
Immunobiology,
C R Parker, and
A K Stankovic, and
C Harlin, and
L Carden
January 2004,
Acta biochimica Polonica,
