BIOMAT Database Logo BIOMAT Database Logo

Rationale for the use of the ACTH4-9 analogue ORG 2766 in the treatment of diabetic neuropathy. 1992

B Bravenboer, and D W Erkelens, and W H Gispen
Department of Internal Medicine, University Hospital Utrecht, Netherlands.

UI MeSH Term Description Entries
D010446 Peptide Fragments Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques. Peptide Fragment,Fragment, Peptide,Fragments, Peptide
D002945 Cisplatin An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. Platinum Diamminodichloride,cis-Diamminedichloroplatinum(II),cis-Dichlorodiammineplatinum(II),Biocisplatinum,Dichlorodiammineplatinum,NSC-119875,Platidiam,Platino,Platinol,cis-Diamminedichloroplatinum,cis-Platinum,Diamminodichloride, Platinum,cis Diamminedichloroplatinum,cis Platinum
D003929 Diabetic Neuropathies Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325) Diabetic Amyotrophy,Diabetic Autonomic Neuropathy,Diabetic Neuralgia,Diabetic Polyneuropathy,Neuralgia, Diabetic,Asymmetric Diabetic Proximal Motor Neuropathy,Diabetic Asymmetric Polyneuropathy,Diabetic Mononeuropathy,Diabetic Mononeuropathy Simplex,Diabetic Neuropathy, Painful,Mononeuropathy, Diabetic,Symmetric Diabetic Proximal Motor Neuropathy,Amyotrophies, Diabetic,Amyotrophy, Diabetic,Asymmetric Polyneuropathies, Diabetic,Asymmetric Polyneuropathy, Diabetic,Autonomic Neuropathies, Diabetic,Autonomic Neuropathy, Diabetic,Diabetic Amyotrophies,Diabetic Asymmetric Polyneuropathies,Diabetic Autonomic Neuropathies,Diabetic Mononeuropathies,Diabetic Mononeuropathy Simplices,Diabetic Neuralgias,Diabetic Neuropathies, Painful,Diabetic Neuropathy,Diabetic Polyneuropathies,Mononeuropathies, Diabetic,Mononeuropathy Simplex, Diabetic,Mononeuropathy Simplices, Diabetic,Neuralgias, Diabetic,Neuropathies, Diabetic,Neuropathies, Diabetic Autonomic,Neuropathies, Painful Diabetic,Neuropathy, Diabetic,Neuropathy, Diabetic Autonomic,Neuropathy, Painful Diabetic,Painful Diabetic Neuropathies,Painful Diabetic Neuropathy,Polyneuropathies, Diabetic,Polyneuropathies, Diabetic Asymmetric,Polyneuropathy, Diabetic,Polyneuropathy, Diabetic Asymmetric,Simplex, Diabetic Mononeuropathy,Simplices, Diabetic Mononeuropathy
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000324 Adrenocorticotropic Hormone An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP). ACTH,Adrenocorticotropin,Corticotropin,1-39 ACTH,ACTH (1-39),Adrenocorticotrophic Hormone,Corticotrophin,Corticotrophin (1-39),Corticotropin (1-39),Hormone, Adrenocorticotrophic,Hormone, Adrenocorticotropic
D000927 Anticonvulsants Drugs used to prevent SEIZURES or reduce their severity. Anticonvulsant,Anticonvulsant Drug,Anticonvulsive Agent,Anticonvulsive Drug,Antiepileptic,Antiepileptic Agent,Antiepileptic Agents,Antiepileptic Drug,Anticonvulsant Drugs,Anticonvulsive Agents,Anticonvulsive Drugs,Antiepileptic Drugs,Antiepileptics,Agent, Anticonvulsive,Agent, Antiepileptic,Agents, Anticonvulsive,Agents, Antiepileptic,Drug, Anticonvulsant,Drug, Anticonvulsive,Drug, Antiepileptic,Drugs, Anticonvulsant,Drugs, Anticonvulsive,Drugs, Antiepileptic

Related Publications

B Bravenboer, and D W Erkelens, and W H Gispen
Effects of ORG 2766, a neurotrophic ACTH4-9 analogue, in neuroblastoma cells.
May 1993, Annals of the New York Academy of Sciences,
B Bravenboer, and D W Erkelens, and W H Gispen
Trial of an ACTH4-9 Analogue (ORG 2766) in children with intractable seizures.
May 1982, Neuropediatrics,
B Bravenboer, and D W Erkelens, and W H Gispen
Spatial learning and the hippocampal corticosterone receptor system of old rats: effect of the ACTH4-9 analogue ORG 2766.
September 1984, Brain research,
B Bravenboer, and D W Erkelens, and W H Gispen
alpha-MSH and ACTH4-9 analogue Org 2766 induce a cAMP increase in cultured rat spinal cord cells.
May 1993, Annals of the New York Academy of Sciences,
B Bravenboer, and D W Erkelens, and W H Gispen
An ACTH-(4-9) analogue, Org 2766, improves recovery from acrylamide neuropathy in rats.
September 1990, European journal of pharmacology,
B Bravenboer, and D W Erkelens, and W H Gispen
An ACTH4-9 analog (ORG 2766) speeds recovery from septal hyperemotionality in the rat.
September 1983, Behavioral and neural biology,
B Bravenboer, and D W Erkelens, and W H Gispen
Cerebral 2-deoxyglucose accumulation in mice following chronic treatment with an ACTH4-9 analog, ORG 2766.
April 1984, Brain research bulletin,
B Bravenboer, and D W Erkelens, and W H Gispen
ACTH4-9 analog (ORG 2766) facilitates acquisition of an inhibitory avoidance response in rats.
January 1979, Pharmacology, biochemistry, and behavior,
B Bravenboer, and D W Erkelens, and W H Gispen
Induction of analgesia by central administration of ORG 2766, an analog of ACTH4--9.
January 1981, European journal of pharmacology,
B Bravenboer, and D W Erkelens, and W H Gispen
A synthetic ACTH4-9 analogue )Organon 2766) and sleep in healthy man.
December 1980, Neuropharmacology,
Copied contents to your clipboard!