Biomaterial Database

[Experimental infection with hepatitis E virus in rhesus monkeys]. 1992

Z Li

Beijing viral Hepatitis Research Institute.

An experimental model of hepatitis E was established in Rhesus Monkeys. Four animals were inoculated with stool suspensions that obtained from patients with hepatitis E. Two animals injected with PBS were taken as negative controls. After 4-6 weeks the ALT of the four animals infected HEV raised 3-4 times and the live biopsy showed acidophilic degeneration of hepatocytes and coagulative liver cell necrosis. Acidophilic bodies were frequently observed. Foci of lytic single-cell necrosis were also observed. Degenerative and microinflammatory changes in liver parenchyma in zones 1-2 of liver lobules were accompanied by inconspicuous infiltrations in portal tracts. 27-34 nm virus-like particles were recovered from the stools of infection animals by IEM.

UI	MeSH Term	Description	Entries
D008253	Macaca mulatta	A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.	Chinese Rhesus Macaques,Macaca mulatta lasiota,Monkey, Rhesus,Rhesus Monkey,Rhesus Macaque,Chinese Rhesus Macaque,Macaca mulatta lasiotas,Macaque, Rhesus,Rhesus Macaque, Chinese,Rhesus Macaques,Rhesus Macaques, Chinese,Rhesus Monkeys
D008297	Male		Males
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012367	RNA, Viral	Ribonucleic acid that makes up the genetic material of viruses.	Viral RNA
D016133	Polymerase Chain Reaction	In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.	Anchored PCR,Inverse PCR,Nested PCR,PCR,Anchored Polymerase Chain Reaction,Inverse Polymerase Chain Reaction,Nested Polymerase Chain Reaction,PCR, Anchored,PCR, Inverse,PCR, Nested,Polymerase Chain Reactions,Reaction, Polymerase Chain,Reactions, Polymerase Chain
D016751	Hepatitis E	Acute INFLAMMATION of the LIVER in humans; caused by HEPATITIS E VIRUS, a non-enveloped single-stranded RNA virus. Similar to HEPATITIS A, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission.	Enterically-Transmitted Non-A, Non-B Hepatitis,Epidemic Non-A, Non-B Hepatitis,Hepatitis, Viral, Non-A, Non-B, Enterically-Transmitted,Hepatitis, Water-Borne,ET-NANBH,Enterically Transmitted Non A, Non B Hepatitis,Epidemic Non A, Non B Hepatitis,Hepatitides, Water-Borne,Hepatitis, Water Borne,Water-Borne Hepatitides,Water-Borne Hepatitis
D016752	Hepatitis E virus	A positive-stranded RNA virus species, causing enterically-transmitted non-A, non-B hepatitis (HEPATITIS E).	Hepatitis E virus (strain Burma),Orthohepevirus A,Paslahepevirus,Paslahepevirus balayani,Paslahepeviruses