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The effect of 30 min substrate free hypoxia (H) on isometric tension was studied in isolated myocardium (M) of adult (A) and newborn (N) rats. The perfusion with 50% Na+ H solution caused in AM the development of H contracture which was more than 50% higher than control contracture. H perfusion with 0.1 mM Ca2+, 1.0 mM La3+, and 10.0 mM of caffeine provides the discrimination of control and hypoNa+ contractures. It is assumed that early H contracture in AM is a result of inability of Ca-sequestering system to accumulate intracellular Ca2+ and Ca2+ influxing through the sarcolemma. In myocardium of N rats Na-Ca exchange is proposed as a main source of Ca2+ for H contracture development.
G I Mashanov, and
P B Tsyvían, and
O G Arteméva
December 1982,
Circulation research,
G I Mashanov, and
P B Tsyvían, and
O G Arteméva
November 1983,
European heart journal,
G I Mashanov, and
P B Tsyvían, and
O G Arteméva
October 1993,
The Journal of thoracic and cardiovascular surgery,
G I Mashanov, and
P B Tsyvían, and
O G Arteméva
September 1989,
Journal of molecular and cellular cardiology,
G I Mashanov, and
P B Tsyvían, and
O G Arteméva
January 1985,
Pediatric pharmacology (New York, N.Y.),
G I Mashanov, and
P B Tsyvían, and
O G Arteméva
June 1988,
Biulleten' eksperimental'noi biologii i meditsiny,
G I Mashanov, and
P B Tsyvían, and
O G Arteméva
January 1980,
Patologia polska,
G I Mashanov, and
P B Tsyvían, and
O G Arteméva
January 1981,
Patologicheskaia fiziologiia i eksperimental'naia terapiia,
G I Mashanov, and
P B Tsyvían, and
O G Arteméva
January 1989,
Acta medicinae legalis et socialis,
G I Mashanov, and
P B Tsyvían, and
O G Arteméva
August 1986,
Anaesthesia and intensive care,
